92例晚期上颌窦鳞癌患者的临床疗效分析  

Treatment of Advanced Maxillary Sinus Squamous Carcinoma: An Analysis of 92 Cases

作　　者：苏耀荣[1] 伍国号[1] 曾宗渊[1] 郭朱明[1] 陈文宽[1] 魏茂文[1] 陈艳峰[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2008年第5期535-538,共4页Chinese Journal of Cancer

摘　　要：背景与目的:晚期上颌窦鳞癌的治疗效果较差,其有效治疗方式目前也尚未有统一意见。本研究旨在探讨晚期上颌窦鳞癌的合理治疗方法。方法:回顾性分析中山大学肿瘤防治中心1978年1月至2001年12月间T3、T4期上颌窦鳞癌患者92例的临床资料,按治疗方式不同,分为单纯放疗组21例,单纯手术组8例,综合治疗组63例(其中手术结合放疗51例,化疗+放疗12例)。结果:单纯放疗组3年和5年生存率分别为19.0%、9.5%,单纯手术组3年和5年生存率分别为25.0%、12.5%,综合治疗组3年和5年生存率分别为46.0%、33.3%。单纯放疗组及单纯手术组分别与综合治疗组比较,其3年和5年生存率的差异均有统计学意义(P<0.05)。在综合治疗组中,术前放疗+手术患者3年和5年生存率分别为33.3%、23.8%,手术+术后放疗患者3年和5年生存率分别为52.9%、47.1%,术前放疗+手术+术后放疗患者3年和5年生存率分别为53.8%、30.8%,化疗+放疗患者3年和5年生存率分别为50.0%、33.3%,在综合治疗组中各不同治疗组合间的临床疗效比较,差异无统计学意义(P>0.05)。结论:晚期上颌窦鳞癌行单一治疗效果较差,行综合治疗效果较好。如何制定以手术为主,有机结合放疗、化疗的最佳治疗模式,还有待进一步探讨。BACKGROUND ＆ OBJECTIVE： There is no satisfactory treatment for advanced maxillary sinus squamous carcinoma. The treatment strategy is controversial. This study aimed to explore a rational treatment for advanced maxillary sinus squamous carcinoma. METHODS： Clinical data of 92 patients with stage T3-T4 maxillary sinus squamous cell carcinoma, treated in Cancer Center of Sun Yat-sen University from Jan.1978 to Dec. 2001, were reviewed. Of the 92 patients, 21 received radiotherapy alone, 8 received surgery alone, 63 received multimodality therapy （51 received surgery combined with radiotherapy, and 12 received chemoradiotherapy）. RESULTS： The 3- and 5-year survival rates were significantly lower in radiotherapy group and surgery group than in multimodality therapy group （19.0% and 25.0% vs. 46.0%, P〈0.05; 9.5% and 12.5% vs. 33.3%, P〈 0.05）. In multimodality therapy group, the 3- and 5-year survival rates were 33.3% and 23.8% for the patients who received radiotherapy followed by surgery, 52.9% and 47.1% for the patients who received surgery follow by radiotherapy, 53.8% and 30.8% for the patients who received pre- and postoperative radiotherapy, and 50.0% and 33.3% for the patients who received chemoradiotherapy. There were no significant differences in survival rate between these four subgroups （P〉0.05）. CONCLUSIONS： The efficacy of multimodality therapy is better than that of single therapy strategy for advanced maxillary sinus squamous carcinoma. The best treatment pattern for advanced maxillary sinus squamous carcinoma needs further research.

关 键 词：上颌窦肿瘤 鳞状细胞癌 综合治疗 生存率 

分 类 号：R739.6[医药卫生—肿瘤]