健择和氟尿嘧啶联合适形放疗对局部晚期胰腺癌的疗效分析  

The effect of combination chemotherapy of gemcitabine and 5-FU plus three dimensional conformal radiotherapy on locally advanced pancreatic cancer

作　　者：丁兆军[1] 陈玉[1] 周嘉云[1] 安永恒[2] 

机构地区：[1]山东省日照市人民医院肿瘤科,276800 [2]青岛大学附属医院肿瘤中心

出　　处：《中国临床实用医学》2008年第4期42-43,共2页China Clinical Practical Medicine

摘　　要：目的评价健择和氟尿嘧啶（GF）联合适形放疗对局部晚期胰腺癌的疗效。方法前瞻性分析了2002年3月至2006年4月收治的54例局部晚期胰腺癌患者的疗效，其中25例采用GF化疗联合适形放疗（试验组），29例单纯采用GF化疗（对照组）。结果试验组和对照组的有效率（CR＋PR）分别为69．6％和39．3％（P=0．0311），远处转移率分别为43．5％和53．6％（P=0．4731），6个月生存率分别为78．3％和53．6％（P=0．0664），1年生存率分别为52．2％和25．0％（P=0．0458）；临床获益率（CBR）分别为82．6％和60．7％（P=0．0877），严重不良事件发生率分别为43．4％和32．1％（P=0．4048）。结论健择和氟尿嘧啶联合适形放射治疗局部晚期胰腺癌，在近期有效率、1年生存率方面优于单纯GF化疗，但在临床获益率、远处转移率、6月生存率及严重不良事件方面，二者无明显差异。Objective To evaluate the effect of combination chemotherapy of gemcitabine and 5-FU plus three dimensional conformal radiotherapy on patients with locally acvanced pancreatic cancer. Methods 54 patients with locally advanced pancreatic cancer from March 2002 to April 2006 were enrolled ,one of 25 patients were treated with combination chemotherapy of GF plus three dimensional conformal radiotherapy （ experiment group） , the other 29 patients were treated only with combination chemotherapy of GF （control group）. Resuits The general remission rate（ CR ＋ PR） was 69.6% in experiment group and 39.3% in control group （Х^2 = 4. 6471 ,P =0. 031 1 ）. There were no statistical difference between the two groups in metastases rates （43.5% vs53.6% ,P = 0. 473 1 ） , survival rates of six months （78.3% vs53.6% , P =0. 066 4 ） , clinical benefit response （ 82.6% vs60.7% ,P = 0. 087 7 ） and grave adverse events （43.4% vs32.1% , P = 0. 404 8 ） , but there were significant difference in survival rates of one year between two groups （53.6% vs25.0% , P = 0. 045 8 ）. Conclusion Combination chemotherapy of GF plus three dimensional conformal radiotherapy might be better than single combination chemotherapy of GF in general remission rates and survival rates of twelve months in patients with locally advanced pancreatic cancer,but there were no difference between two groups in clinical benefit response, metastases rates, survival rates of six months and grave adverse events.

关 键 词：适形放射治疗 胰腺癌 化学治疗 健择 

分 类 号：R735.9[医药卫生—肿瘤] R730.55[医药卫生—临床医学]