吸收系数法测定阿司咪唑片的含量、含量均匀度及溶出度  

The Specific Absorptivity Determination of Content,Content Uniformity and Dissolution in Astemizoli Tablets

作　　者：柳小秦 吴少平 李霞 尹琳 徐长根 刘海静 

机构地区：[1]陕西省食品药品检验所,西安710061

出　　处：《中国药品标准》2008年第2期142-144,共3页Drug Standards of China

摘　　要：目的:采用吸收系数法测定阿司咪唑片的含量、含量均匀度及溶出度。方法:屏除了有机溶媒异丙醇,以0.1mol.L-1盐酸溶液为溶剂,超声溶解,根据阿司咪唑的紫外吸收特征选择277nm为测定波长,利用吸收系数法进行测定。结果:阿司咪唑吸收系数E11%cm为296,RSD=0.7%;线性范围4～20mg.L-1(r=0.9997);平均回收率(n=9):100.3%,RSD=0.5%。结论:本法简便、实用、环保、准确度高,适用于阿司咪唑片含量、均匀度及溶出度的测定,可作为阿司咪唑片的质量控制方法。Objective：To establish a Specific absorptivity method for determination of Content, Content uniformity and dissolution in Astemizoli Tablets. Methods：The sample was extracted with 0, 1 mol · L^-1 HCl solution through supersonic wave. The maximum absorption was 277nm. Results：E1cm^1% was 295 （ RSD = 0.7 % ）. The calibration curves showed good linearity in the range of 4 - 20 mg · L^ - 1 （ r = 0. 9997 ）. The average recovery rate （ n = 9） was 100. 3 % （RSD = 0. 5 % ）, Conclusion：The method is convenient, accurate and environmental. It can be applied tO the quality control of Astemizoli Tablets.

关 键 词：阿司咪唑片 吸收系数法 含量测定 含量均匀度 溶出度 

分 类 号：R976[医药卫生—药品] R975[医药卫生—药学]