纤溶酶原激活物抑制剂-1-675 4G/5G基因及纤维蛋白原β-148C/T基因多态性与脑梗死关系的研究  

The association of beta fibrinogen-148 C/T gene and plasminogen activator inhibitor 1-675 4G/5G gene polymorphisms with cerebral infarction

作　　者：刘洲[1] 赵斌[1] 

机构地区：[1]广东医学院附属医院神经内科,524001

出　　处：《神经疾病与精神卫生》2008年第2期94-97,共4页Journal of Neuroscience and Mental Health

基　　金：广东省自然科学基金面上项目(7009941)

摘　　要：目的探讨纤溶酶原激活物抑制剂-1（PAI-1）-675 4G/5G及纤维蛋白原（Fg）β-148C/T基因多态性与脑梗死的关系。方法检测140例健康体检者（对照组）和220例脑梗死患者（CI组）PAI-1-675 4G/5G及Fgβ-148C/T基因多态性,并分析两组基因在正常人群及脑梗死患者中的频率分布特点。结果CI组Fgβ-148C/T位点T等位基因频率为0.33,对照组为0.225,两组比较差异具有统计学意义（P=0.0026）。CI组PAI-1-675 4G等位基因频率为0.48,对照组为0.56,两组比较差异具有统计学意义（P=0.037）,以5G/5G基因型作为参考,4G/4G基因型发生CI的OR值为0.52（95%CI：0.282～0.958,P=0.027）;携带CC和4G/4G基因型发生CI的OR值为0.48（95%CI：0.253～0.91,P=0.023）。结论本研究发现Fgβ-148T等位基因是CI发病的危险因素,4G/4G纯合子是CI的保护因素,CC基因型加强4G/4G基因型的CI保护作用。Objective To investigated the correlations of plasminogen activator inhibitor 1（PAI- 1）-675 4G/SG gene polymorphism, beta fibrinogen-148C/T （Fgβ-148C/T） gene polymorphism and cerebral infarction （CI）. Methods PAI-1 -675 4G/SG and Fgβ--148C/T genotypes of 220 cases and 140 health individual controls were identified, and their frequency distribution were analyzed. Results The frequencies of Fgβ-148C/T T allele in CI group and control group were 0.33 and 0. 225, respectively （ P=0.0 026）, and the frequencies of PAI-1 -675 4G/SG 4G alleles in CI group and control group were 0.48 and 0.56, respectively （ P = 0. 037）. When considering 5G/SG homozygote as reference, the odds ratio （OR） was 0.52 （95% CI： 0. 282～0. 958, P=0. 027） for 4G/4G homozygote. The risk factor of CI was 0.48 （95% CI： 0. 253～0.91 P =0. 023） for those with CC and 4G/4G genotypes. Conclusions The findings suggest that Fgβ-148T allele are risk factors of CI. PAI-1 - 675 4G/4G homozygote is a protective factor for CI. CC genotype strengthens the protective effect of 4G/4G genotype for CI.

关 键 词：纤维蛋白原 纤溶酶原激活物抑制剂-1 脑梗死 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]