结肠黑变病色素性质和病因与泻剂关系的研究与问题  

The researches on the coloring matter and the causes of the Melanosis coli and the relationship between Melanosis coli,Aloe,and Rhizome

作　　者：万金志[1] 徐新军[1] 郭惠学[2] 方炜[1] 刘佑波 

机构地区：[1]中山大学药学院,广东广州510080 [2]中山大学附属第五医院,广东珠海519000 [3]深圳市平湖医院,广东深圳518111

出　　处：《国际内科学杂志》2008年第4期227-229,F0003,共4页International Journal of Internal Medicine

基　　金：2005年度广东省中医药局科研立项课题(1050163);2005年珠海市科技计划项目资助课题(PC20051072)

摘　　要：芦荟、大黄是两种作用特别,应用广泛的中药,大量的患者长期应用,但这两种药物长期使用的安全性一直存在着争议,并已引起医药界和社会的关注,目前临床上所报道的毒性反应主要集中在结肠黑变病上。对于结肠黑变病的病因,结肠黑变病与芦荟、大黄类泻剂的关系国内外作了不少的研究,但仍未得到公认的结果,本文结合在研究的课题对此进行了分析讨论并提出我们的一点思考。Aloe and Rhizome are two kinds of Chinese herbal medicine that are widely used. Much attention has been paid to the safety of the two Chinese herbals after long-term administration. Recently the main clinical reports on the toxicities were focused on their activity causing Melanosis coli （MC）. Many of researches on the causes of MC and the relationship between MC and Aloe, Rhizome have been reported in China and overseas, but not yet got a generally acceptable result. This paper shows an analytieal discussion of the relationship between MC and Aloe, Rhizome.

关 键 词：结肠黑变病 芦荟 大黄 

分 类 号：R574[医药卫生—消化系统]