长春西汀自微乳化释药系统在大鼠小肠的吸收动力学  

Study on the absorption kinetics of vinpocetine self-microemulsifying drug delivery system in rat's intestine

作　　者：陈鹰[1] 陈戈[1] 刘宏[1] 李高[2] 

机构地区：[1]广州军区武汉总医院,湖北武汉430070 [2]华中科技大学同济医学院,湖北武汉430030

出　　处：《中国医院药学杂志》2008年第8期622-626,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究长春西汀自微乳化释药系统(VIN-SMEDDS)在大鼠小肠各部位的吸收情况及影响因素。方法:采用大鼠在体肠循环方法。考察了不同肠段、给药浓度、pH、流速和剂型因素对药物小肠吸收的影响。结果:VIN-SMEDDS在十二指肠、空肠、回肠、结肠部位的药物吸收速率常数(Ka)差异无显著性;给药浓度和pH对药物小肠吸收的Ka值无显著性影响;流速的增加可显著促进药物的吸收;与长春西汀原料粉末及其市售片剂相比,VIN-SMEDDS的Ka值和肠吸收百分率均有显著增加。结论:VIN-SMEDDS在小肠部位的吸收无特定吸收窗,且以被动扩散方式为主,自微乳化释药系统能显著提高长春西汀的溶出和吸收。OBJECTIVE To study the absorption kinetics of vinpocetine（VIN） self-microemulsifying drug delivery system （VIN-SMEDDS） in rat＇s intestine. METHODS The tests were carried out with the use of in situ rat＇s intestine technique. The effects on absorption of different rat＇s intestine segments , concentration of VIN, pH, velocity of flow, and preparation factors were studied. RESULTS There were not significant differences among the absorption constants（Ka） of VIN-SMEDDS at the ileum, jejunum, duodenum and colon. The Ka of VIN-SMEDDS in jejunum was not apparently influenced by different concentration of VIN and PH, but increased with the acceleration of velocity of flow. Compared with vinpocetine powder and commercial tablets, the Ka（h^-1） and Uptake percentage（%） of VIN-SMEDDS were apparently improved. CONCLUSION The absorption of VIN-SMEDDS in rat＇s intestine is a process mainly of the passive diffusion mechanism without specific absorption site. Self- microemulsifying drug delivery system can markedly improve the dissolution and absorption of vinpocetine.

关 键 词：长春西汀 自微乳化释药系统 在体小肠吸收 大鼠 

分 类 号：R96[医药卫生—药理学]