瑞香狼毒总木脂素的体外抗肿瘤活性  

Antitumor activities in vitro of total-lignan from Stellera chamaejasme L.in vitro

作　　者：王彬[1] 贾正平[2] 蔡文清[3] 王敏[2] 李强国[1] 叶丽娟[1] 杨德俊[1] 

机构地区：[1]湘南学院化学与生命科学系,湖南郴州423000 [2]兰州军区兰州总医院药材科,甘肃兰州730050 [3]中国科学院上海有机化学研究所,上海200039

出　　处：《兰州大学学报（自然科学版）》2008年第2期63-65,共3页Journal of Lanzhou University(Natural Sciences)

基　　金：国家自然科学基金(2997205)资助

摘　　要：研究了瑞香狼毒总木脂素的体外抗肿瘤作用.用MTT比色分析法、集落形成法对瑞香狼毒总木脂素的体外抗肿瘤活性进行研究,并与长春新碱的活性进行了比较.瑞香狼毒总木脂素成分对肿瘤细胞株SGC-7901,HEP-7402和HL-60的增殖及克隆形成具有较强的抑制作用,其体外抗肿瘤活性高于或接近于长春新碱,证明瑞香狼毒总木脂素成分具有较强的体外抗肿瘤作用.The antitumor activities in vitro of total-lignan from Stellera chamaejasme were studied in this paper and the in vitro antitumor activities were determined by a MTT assay and clone formation against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma HEP-7402 and leukemia HL-60. Total-lignan has significant inhibition of cell proliferation and clone formation of human cancer cell lines such aS SGC-7901 and BEL-7402, and its antitumor activities in vitro are higher than those of vincristine. Total-lignan from Stellera chamaejasme has a significant antitumor effect in vitro.

关 键 词：瑞香狼毒 总木脂素 抗肿瘤活性 体外 

分 类 号：Q949.761[生物学—植物学]