基质金属蛋白酶2及其抑制剂与头颈部肿瘤  

Relationship of Head and Neck Neoplasms with Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2

作　　者：郑娟[1] 黎万荣[1] 

机构地区：[1]泸州医学院附属医院耳鼻咽喉头颈外科,四川泸州646000

出　　处：《医学综述》2008年第9期1315-1317,共3页Medical Recapitulate

摘　　要：肿瘤细胞对组织的侵袭的关键步骤是降解细胞外基质。基质金属蛋白酶通过对基底膜和细胞外基质的降解而促进癌细胞对周围组织的浸润,是降解关键酶。基质金属蛋白酶2是基质金属蛋白酶家族重要成员之一,金属蛋白酶抑制剂2对其有特异性的抑制作用,二者间的失衡在肿瘤浸润转移过程中起重要的作用。而头颈部肿瘤是引起患者死亡的常见肿瘤,研究二者与头颈部肿瘤浸润转移的关系,将对头颈部肿瘤的诊断、治疗及预后有重要意义。The degradation of extracellular matrix is the key step for promotes tumor ceils to infiltrate surrounding tissue by degradating basemental membrane and extracellular matrix, and it is the conclusive enzyme for degradation, matrix metalloproteinase-2 is one of the most important member of matrix metalloproteinases （MMPs） family,which specially inhibited by tissue inhibitor of metalloproteinase-2, and the imbalance between MMP-2 and tissue inhibitor of metalloprotei Nase-2 （TIMP-2） plays an important role in the process of tumor＇s metastasis and invasion. Neoplasms in head and neck are common neoplasms which cause patients＇ death. To study the relationship between the two and the invasion and metastasis of neoplasms in head and neck may contribute to the diagnosis and therapy and prognosis of neoplasms in head and neck.

关 键 词：头颈部肿瘤 基质金属蛋白酶2 金属蛋白酶组织抑制因子2 诊断 预后 

分 类 号：R739.91[医药卫生—肿瘤]