甲状腺癌组织MVD和β-连环素蛋白表达及其相关性研究  

The Relationship between Microvessel Density and the Expression ofβ-catenin Protein in Thyroid Carcinoma

作　　者：王化修[1] 李景和[2] 肖小芹[1] 

机构地区：[1]邵阳医学高等专科学校病理教研室,湖南邵阳422000 [2]中南大学湘雅基础医学院病理学系,湖南长沙410008

出　　处：《现代生物医学进展》2008年第7期1276-1279,共4页Progress in Modern Biomedicine

基　　金：湖南省科技计划项目(2007FJ3092);湖南省普通高校青年骨干教师培养基金(湘教通[2007]214);湖南省教育厅科研基金(06C076)

摘　　要：目的:探讨微血管密度(MVD)和β-catenin蛋白表达在甲状腺癌预后判断中的意义。方法:采用免疫组化SP法检测90例甲状腺癌及10例正常甲状腺组织中β-catenin蛋白表达,以CD_(105)标记测定MVD。结果:①MVD值在甲状腺髓样癌、乳头状癌、未分化癌、滤泡癌中依次增高(P<0.05);伴发转移及高临床分期(Ⅲ、Ⅳ期)甲状腺癌组织中MVD明显高于无转移及低临床分期(Ⅰ、Ⅱ期)组(P<0.05)。②未分化癌及髓样癌中β-catenin异常表达率显著高于其在乳头状癌及滤泡癌中的表达(P<0.05),β-catenin异常表达率在淋巴结有无转移间以及病理分期Ⅰ～Ⅱ、Ⅲ～Ⅳ之间的差异有统计学意义(P<0.05)。③β-catenin异常表达与甲状腺癌MVD值呈显著正相关(r=0.384,P<0.05)。结论:MVD是影响甲状腺癌预后的因素之一,β-catenin可能在甲状腺癌组织微血管形成中发挥作用。Objective： To investigate the correlation between microvessel density （MVD） and theexpression of β-catenin protein in thyroid caecinoma and its prognostic significance. Methods： The expression β-catenin protein and MVD marked with CD105 in 90 cases of thyroid carcinoma tissues and 10 cases of normal tissues surrounding thyroid adenoma. Results： ①Microvessel density （MVD） value was increased sequentially in medullary thyroid carcinoma （MTC）, papillary thyroid carcinoma （ PTC ）, undifferentiated thyroid carcinoma（UTC ） and follicular thyroid carcinoma （FTC）. There was significant difference between groups （p〈0.05）. Furthermore, the MVD value in thyroid carcinoma with lymph node metastasis was significantly higher than those of in cases without lymph node metastasis （p〈0.05）, as well as in between clinical stage Ⅲ-Ⅳ and Ⅰ-Ⅱ. ②The abnormal expression rate of β-catenin in UTC and MTC was significantly higher than those of in PTC and FTC （p〈0.05）. There was significant positive relationships between abnormal expression of β-catenin with the lymph node metastasis and the clinical stage of thyroid carcinoma （p〈0.05）. ③The abnormal expression of β-catenin protein and MVD were positively correlated （r=0.384, P〈0.05 ）. Conclusion： MVD were a prognostic factors, β-catenin might promote angiogenesis in thyroid carcinoma.

关 键 词：甲状腺癌 微血管密度 Β-连环素 CD105 

分 类 号：R736.1[医药卫生—肿瘤]