肠易激综合征患者结肠黏膜P物质、血管活性肠肽和肥大细胞的变化  

Changes of Substance P, Vasoactive Intestinal Peptide and Mast Cell in Colonic Mucosa of Patients with Irritable Bowel Syndrome

作　　者：陈晓敏[1] 张燕华[1] 毛峻岭[1] 张赛森[1] 陆伦根[2] 

机构地区：[1]上海交通大学医学院附属仁济医院嘉定分院消化内科,201800 [2]上海交通大学医学院附属仁济医院消化内科

出　　处：《胃肠病学》2008年第4期228-230,共3页Chinese Journal of Gastroenterology

摘　　要：背景:肠易激综合征(IBS)的发病机制尚不明确。目的:探讨IBS患者结肠黏膜P物质(SP)、血管活性肠肽(VIP)、肥大细胞(MC)的变化及其在IBS中的可能作用。方法:20例腹泻型IBS患者、22例便秘型IBS患者和18名正常对照者纳入本研究,取回盲部、乙状结肠黏膜行SP、VIP免疫组化染色和MC计数。结果:IBS患者回盲部、乙状结肠黏膜SP、VIP免疫阳性神经纤维较正常对照组增多、增粗,阳性增强(P<0.05)。IBS患者乙状结肠黏膜SP、VIP免疫阳性神经纤维与回盲部相比无显著差异。IBS患者回盲部黏膜MC计数较正常对照组显著增高(P<0.01),乙状结肠黏膜MC计数与正常对照组相比无显著差异。IBS患者乙状结肠黏膜MC计数与正常对照组相比,显著低于回盲部(P<0.01)。结论:SP、VIP和MC在IBS的发病中起有一定作用。Background： The pathogenesis of irritable bowel syndrome （IBS） is still unclear. Aims： To investigate the changes of substance P （SP）, vasoactive intestinal peptide （VIP） and mast cell （MC） in colonic mucosa of patients with IBS, and to study their possible roles in IBS. Methods： Twenty diarrhea-predominant IBS patients, 22 constipation-predominant IBS patients and 18 normal controls were enrolled. SP and VIP were studied by immunohistochemistry, and the number of MC was counted in two biopsied sections from ileocecal and sigmoid colonic mucosa. Results： Immunoreactive nerve fibers of SP and VIP were markedly higher in density and degree in both ileocecal and sigmoid colonic mucosa in IBS group than those in normal control group （P〈0.05）. No significant differences in immunoreactive nerve fibers of SP and VIP were found between sigmoid colonic and ileocecal mucosa in IBS patients. Compared with normal control group, the number of MC in ileocecal mucosa in IBS patients was significantly increased （P〈0.01）, but no significant difference was found in sigmoid colonic mucosa in IBS patients. The number of MC in sigmoid colonic mucosa was markedly lower than that in ileocecal mucosa in IBS patients （P〈0.01）. Conclusions： SP, VIP and MC play some roles in the pathogenesis of IBS.

关 键 词：肠易激综合征 P物质 血管活性肠肽 肥大细胞 

分 类 号：R574[医药卫生—消化系统]