BK通道的生物物理特性及其门控  

Biophysical properties and gating of the BK ion channels

作　　者：高晓晖[1] 赵虎成[2] 

机构地区：[1]清华大学生物科学与技术系,北京100084 [2]清华大学生物力学与医学工程研究所,北京100084

出　　处：《医用生物力学》2008年第2期171-176,共6页Journal of Medical Biomechanics

摘　　要：大电导——钙离子激活的K+通道(BK通道)广泛地表达于各种组织与细胞中,具有重要的生理功能。这一类离子通道同时具有钾通道家族的多种生物物理特性,包括选择透过性、电压依赖性门控、配体结合(Ca2+激活)门控,以及应力敏感性。对其结构的分析,有助于更深入了解BK离子通道及其整个K+通道家族的门控机制。通过家族共性与BK通道特异性的分析,将有助于阐明BK通道的结构及其门控机制。本文结合钾离子通道家族结构与功能的相关研究,论述了BK通道分子结构、功能及其门控机制。Large conductance, Ca^2＋-activated K^＋ channels （BK channels）are widely expressed in various cells and tissues, which have the important physiological functions. Such kind of channels also has many biophysical properties of other members＇ in potassium ion channels family,, including the ion selectivity, the voltage-dependent gating, the ligand - dependent （calcium-activated） gating and the stress sensitivity. The structural analysis of BK channels can help to leam more about their own gating mechanism and the gating mechanism of other family members as well. Further more, with analyzing the commonness of the whole family members and the specificity of the BK channels, it will be helpful for us to illuminate the structure and the gating mechanism of BK channels.Based on the correlative study of potassium ion channels family, an in-depth discussion about the molecular structure, function and the gating mechanism of BK channels will be given in this paper.

关 键 词：BK通道 钾离子选择性 门控 Β亚基 

分 类 号：R318.01[医药卫生—生物医学工程]