HIF-1α、VEGF在外阴鳞状细胞癌中的表达与临床意义  

Expressions and the clinical significance of HIF-1 alpha and VEGF in the vulgar squamous cell carcinoma

作　　者：何凯 王慧香[2] 张桂荣 苏丽 谭秀梅 杜绍敏 张雪芹 

机构地区：[1]黑龙江省大庆市油田总医院集团龙南医院妇产科齐齐合尔医学院第五附院,163000 [2]清华大学玉泉医院妇产中心

出　　处：《中国妇幼保健》2008年第14期2005-2006,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨缺氧诱导因子-1α(hypoxia inducible factor-1 alpha,HIF-1α)与血管内皮生长因子(vascular endothelial growth factor,VEGF)在外阴鳞状细胞癌(vulvar squamous cell carcinoma,VSCC)中的表达及其相互关系。方法:用免疫组化SP法检查43例VSCC中HIF-1α、VEGF蛋白表达。结果:VSCC中HIF-1α与VEGF阳性表达率分别为72.09%(31/43),76.74%(33/43),均明显高于外阴正常表皮(P<0.01)。随着病理分级、临床分期的增加及淋巴结转移的发生,HIF-1α与VEGF阳性表达率也随之增加,差异有显著性(P<0.05)。HIF-1α与VEGF表达呈正相关(rs=0.866,P<0.01)。结论:HIF-1α、VEGF是反映VSCC浸润转移等生物学行为的重要指标,HIF-1α诱导VEGF表达从而促进肿瘤血管生成可能参与VSCC的进展。Objective： To explore the expression of hypoxia inducible factor - 1 alpha （ HIF -1α） and vascular endothelial growth factor （VEGF） in vulvar squamous cell carcinomas （VSCC） and their relationship. Methods： The expression of the HIF -1α product was detected by immunochemistry in the tissue samples of 10 cases of normal vulvas and 43 cases of VSCC. Results： The positive rates of HIF -1α and VEGF protein in the VSCC were 72. 09% （31/43） and 76.74% （33/43） respectively, with significant difference from the control group （ P 〈 0. 01 ） . With the increase of pathological grades, clinical stages and the occurrence of lymphode metastasis, the positive expression rates of HIF -1α and VEGF protein in the VSCC raised （ P 〈 0. 05 ） . There was a positive correlation between HIF -1α and VEGF （ ra = 0. 866, P 〈 0. 01 ） . Conclusion： HIF -1α may play an important role in angiogenesis and tumor progression by regulating the expression of VEGF in VSCC.

关 键 词：外阴鳞状细胞癌 HIF-1Α 免疫组织化学 

分 类 号：R737.35[医药卫生—肿瘤]