Runx3在溃疡性结肠炎中的表达  

The Expression of Runx3 in Ulcerous Colitis

作　　者：姚芳芳[1] 郭长存[1] 贺莉[1] 韩霜[1] 丁杰[1] 

机构地区：[1]第四军医大学西京医院消化内科肿瘤生物学国家重点实验室

出　　处：《现代生物医学进展》2008年第6期1119-1121,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30400540)

摘　　要：目的:观察Runx3在溃疡性结肠炎(UC)粘膜组织中的表达,探讨抑癌基因RUNX3在溃疡性结肠炎发病机制中的调控作用。方法:选取经过临床表现、内镜、病理等方法共同确诊的溃疡性结肠炎活检的石蜡标本和结肠癌手术切除标本残端的正常组织石蜡标本,用免疫组织化学的方法检测Runx3蛋白在68例UC及50例对照结肠粘膜组织中的表达情况。结果:Runx3在UC及对照组结肠粘膜组织中均有表达,两者之间的差异无统计学意义(P>0.05)。Runx3的表达与UC患者的性别、年龄及病变严重程度之间无显著性相关(P>0.05)。结论:Runx3作为一个转录因子在溃疡性结肠炎的发病机制中可能通过非直接的方式发挥其重要作用。Objective To observe the expression of Runx3 in pathogenesis of ulcerative colitis （UC） and investigate the effect of Runx3 on inhibiting cancer. Method The pathological paraffin embedded tissues were selected from UC which was diagnosed by clinical, endoscopic and histological criteria and the normal tissues were from the nub of the samples whose carcinoma of colon was surgical cut. The expression of Runx3 in the samples was detected by immunohistochemistry method. Results The positive rate of the expression in UC tissues was 76.5 %, and there was no significantly difference between UC tissues and normal tissues （66.0%） （P〉0.05）. The expression level of Runx3 was not closely related to the age and sex. Conclusions Runx3 may be an important regulatory factor in ulcerative colitis which acts as a transcriptional factor by indirect means.

关 键 词：RUNX3 溃疡性结肠炎 免疫组化 

分 类 号：R-332[医药卫生] R322.61