人胰腺癌组织中Livin和IGF-2的表达及临床意义  

Clinical significance of Livin and IGF-2 expression in pancreatic carcinoma

作　　者：周华[1] 常宏[1] 穆庆岭[1] 徐健[1] 秦成坤[1] 张振海[1] 

机构地区：[1]山东大学附属省立医院肝胆外科,山东济南250021

出　　处：《中国现代普通外科进展》2008年第2期114-116,共3页Chinese Journal of Current Advances in General Surgery

基　　金：山东省卫生科技发展计划重点项目(2005ZD03)

摘　　要：目的:探讨人胰腺癌组织中凋亡抑制蛋白Livin表达情况及其与各临床病理因素的关系,以及与胰岛素样生长因子-2(Insulin-like growth factor-2,IGF-2)表达的相关性。方法:应用免疫组织化学SP法检测56例胰腺癌组织中Livin与IGF-2的表达。结果:胰腺癌组织中34例Livin表达阳性,阳性率为60.7%;35例IGF-2表达阳性,阳性率为62.5%;胰腺癌组织Livin、IGF-2的表达阳性率均高于非肿瘤胰腺组织(P<0.05)。Livin和IGF-2的表达与肿瘤组织学分级、临床病理分期及淋巴结转移密切相关(P<0.05)。相关性检验示Livin的表达与IGF-2之间有相关性(P<0.01)。结论:人胰腺癌组织中Livin与IGF-2表达均上调;IGF-2与Livin相互作用共同参与人胰腺癌的发生、发展。Obeetive： To study the expression of Livin and IGF-2 in human pancreatic carcinoma and to explore the relationship between their expression.Metheds Expression of Livin and IGF-2 was assessed by Labelled Streptavindin biotin. Results：Livin and IGF-2 expression were detected in 34/56 （60.7%）, 35/56 （62.5%） respectively. The expression rate of Livin and IGF-2 was higher in pancreatic carcinoma group than that of the non-tumorous pancreas groups （P 〈0.05） There was a close correlation between the expression of Livin and IGF-2 （P 〈 0.01）. Conclusion：Livin and IGF-2 were over-expressed in pancreatic carcinoma tissues. The up-regulation of Livin and IGF-2 had a close correlation.

关 键 词：胰腺肿瘤 LIVIN 胰岛素样生长因子-2 

分 类 号：R735.7[医药卫生—肿瘤]