乳腺癌术前中医辨证与肿瘤增殖因子相关性研究  

Study of Relationship between Syndrome Pattern of Traditional Chinese Medicine and Proliferative Factors of Breast Cancer

作　　者：宋爱莉[1] 殷玉琨[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011

出　　处：《中华中医药学刊》2008年第5期907-909,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨乳腺癌术前中医辨证与肿瘤增殖因子DNA倍体、S期细胞比例及Ki-67表达的相关性。方法:对160例乳腺癌患者术前中医辨证分型,术后手术标本进行DNA倍体、S期细胞比例、Ki-67检测,并做相关性分析。结果:乳腺癌患者术前辨证为正虚毒炽者DNA倍体异倍体、S期细胞比例为高度及Ki-67阳性出现率高于肝郁痰凝组和冲任失调组。经统计学处理,有显著差异(P<0.05)。结论:乳腺癌术前中医辨证与肿瘤增殖因子DNA倍体、S期细胞比例及Ki-67表达有相关性,随着患者中医辨证为肝郁痰凝证、冲任失调证、正虚毒炽证的不同,肿瘤的增殖能力依次增强,预后也更差。Objective ： A study was conducted to find the relationship between the syndrome pattern of traditional Chinese medicine and proliferative factors of breast cancer such as DNA haploid, S phase cell percentage and Ki - 67. Methods ：Choose 160 patients who suffered breast cancer primarily to group into different syndromes. Detect the DNA haploids ,S phase cell percentage and Ki -67 expression. Then chisquare inspection. Results ： Through detecting, heteroploid percentage, S phase cell percentage and Ki - 67 positive expression of the patient who suffered breast cancer grouped in the zhengqi - weak - evil - strong type is the higher than the the other two typies. Through chisquare inspection there is markedness disparity among them（ P 〈0.05）. Conclusion ： DNA haploid, S phase cell percentage and Ki - 67 can reflect the evolvement rule of the types of breast cancer. Different types of breast cancer can reflect the level of proliferation of cancer cell, than clue to the possible prognosis and guide the clinic. Clue to the possible to backspin and slow up the grow of cancer cells from the point of syndrome pattern of traditional Chinese medicine.

关 键 词：乳腺癌 中医辨证 DNA倍体 S期细胞比例 KI-67 

分 类 号：R737.9[医药卫生—肿瘤]