NDRG1和E-cadherin在大肠癌中的表达研究  

Expression of NDRG1 and E-cadherin in colorectal cancers

作　　者：金承俊[1] 朴大勋[1] 金银姬[2] 陈华[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院泌尿外科,黑龙江哈尔滨150001 [2]哈尔滨医科大学病理学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2008年第2期153-156,共4页Journal of Harbin Medical University

摘　　要：目的探讨NDRG1和E-cadherin蛋白在大肠癌组织中的表达、相互关系及临床意义。方法应用免疫组织化学S-P法检测12例正常大肠组织、58例大肠癌组织中NDRG1和E-cadherin蛋白的表达情况。结果①正常大肠组织和大肠癌组织中NDRG1阳性表达率分别为75.00%(9/12)、51.72%(30/58),E-cadherin阳性表达率分别为91.67%(11/12)、55.17%(32/58)。NDRG1和E-cadherin在大肠癌组织中阳性表达率均低于正常大肠组织阳性表达率;②NDRG1和E-cadherin的表达与大肠癌的Dukes分期、淋巴结转移、肝转移显著相关(P<0.05)。E-cadherin的异常表达还与肿瘤的分化程度显著相关(P<0.05);③大肠癌组织中NDRG1和E-cadherin的表达呈正相关(P<0.05)。结论NDRG1、E-cadherin联合检测,可作为预测大肠癌肝转移的有用指标。Objective To investigate the expressions of NDRG1 and E-cadherin in the colorectal cancers and the relationship between them.Methods The expressions of NDRG1 and E-cadherin were detected by S-P immunohistochemical method in 12 normal colorectal tissues and 58 colorectal cancer.Results ①The positive expression rates of NDRG1 were 75.00%（9/12）and 51.72%（30/58）in the normal colorectal tissue and colorectal cancer respectively;the positive expression rates of E-cadherin were 91.67%（11/12）and 55.17%（32/58）in the normal colorectal tissue and colorectal cancer,respectively.Both the positive rates of NDRG1 and E-cadherin expressed in the colorectal cancer were lower than those expressed in the normal colorectal tissue;②The expressions of NDRG1 and E-cadherin were related to the Duke＇s stage,lymph node metastasis,and liver metastasis of colorectal cancer significantly（P〈0.05）.The abnormal expression of E-cadherin was also related to the differentiation of the tumor significantly（P〈0.05）;③The expressions of NDRG1 and E-cadherin were positive related in the colorectal cancer（P〈0.05）.Conclusion Combined detection of NDRG1 and E-cadherin can be used to predict the metastasis of liver in colorectal caner.

关 键 词：大肠癌 NDRG1 E-CADHERIN 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]