补体C3和C4在脑出血后血肿周围组织水肿形成过程中的作用  

Effect of Complement 3 and 4 on Edema Formation around Hematoma after Cerebral Hemorrhage

作　　者：张军[1] 张国华[2] 林杰[3] 

机构地区：[1]河北省石家庄市第一医院,050000 [2]河北医科大学第二医院神经内科,河北省石家庄市050000 [3]河北省邯郸市第一医院神经内科

出　　处：《中国全科医学》2008年第9期741-743,共3页Chinese General Practice

基　　金：河北省自然科学基金资助项目(C2005000748)

摘　　要：目的对脑出血患者血肿周围组织水肿形成与补体C3和C4的关系进行研究,探讨补体在水肿形成过程中的作用。方法50例患者分别于发病的第1、2、3、5、7天采用免疫散射比浊分析法依次检测外周血、血肿液中补体C3和C4的水平并进行影像学检查,同时选取体检正常者10例作为对照组。结果补体C3自发病第1天开始升高,第3天达峰点,第7天降至第1天水平;补体C4及水肿比值的变化与补体C3变化趋势一致。外周血中的补体C3水平在第3天、第5天较对照组差异有统计学意义(P<0.05);而血肿液中补体C3水平在第2天、第3天、第5天较对照组差异有统计学意义(P<0.05);外周血中补体C4在第2、3、5天时较对照组差异有统计学意义(P<0.05);而血肿液补体C4在第3天较对照组差异有统计学意义(P<0.05)。结论补体C3、C4在脑出血后血肿周围组织水肿形成过程中起重要作用。Objective To study the relationship between edema formation around hematoma and complement 3 and 4 （ C3 and C4 ） in patients with cerebral hemorrhage and evaluate the effect of complements on the edema formation. Methods All the patients were divided into four groups; the control, peripheral blood, hematoma and radiology groups. The last three groups were further subdivided as 1 day, 2 day, 3 day, 5 day and 7 day groups. The immunochemistry was taken to detect the C3 and C4 for observing the law of their changes. Results In the normal and peripheral blood groups C3 began to increase from the first day, and reaches to the peak on the third day; it then decreased to the level of the first day. The laws of changes in C4 and ratio of edema were generally consistent with this. Compared with those in the control group, there appeared significant differences in C3 in 3d and 5d subgroups of the peripheral group （ P 〈 0. 05）, and in 2d, 3d and 5d subgroups of the hematoma group （ P 〈 0. 05） ; and there appeared significant differences in C4 in 2d, 3d and 5d subgroups of the peripheral group （ P 〈0.05） , and in3d subgroup of the hematoma group （ P 〈 0. 05 ）. Conclusion C3 and C4 play an important role in edema formation around hematoma after cerebral hemorrhage.

关 键 词：脑出血 脑水肿 补体3 补体4 

分 类 号：R743.34[医药卫生—神经病学与精神病学]