立体定向放射治疗晚期非小细胞肺癌近期疗效观察  

The Observation of Body γ-knife Radiotherpy for Advanced Non-small Cell Lung Cancer

作　　者：李迎春[1] 李宏斌[1] 彭海波[1] 陈成宏[1] 张君洋[1] 苏皓[1] 

机构地区：[1]中国人民解放军第452医院伽玛刀中心,成都610021

出　　处：《肿瘤预防与治疗》2008年第2期155-157,共3页Journal of Cancer Control And Treatment

摘　　要：目的:观察立体定向放射治疗(伽玛刀)晚期非小细胞肺癌的近期疗效和放射副反应。方法:216例非小细胞肺癌患者行伽玛刀放疗。PTV边缘总剂量(50%等剂量曲线)50Gy,分8次~12次,2周完成(肺门肿大淋巴结40Gy),中心最大剂量80Gy^100Gy,CTV边缘总剂量(70%~80%等剂量曲线处)70Gy,50%~80%等剂量曲线覆盖PTV 95%以上。中位随访时间21个月。结果:治疗后3个月~6个月,原发灶完全缓解率(CR)为28.2%(61/216),总有效率为80.3%(173/216)。放射性肺炎、放射性食管炎的发生率分别为21.9%(47/216)、6.25%(13/216)。结论:伽玛刀放射治疗能够有效地提高晚期非小细胞肺癌的局部控制率,并发症低,近期疗效满意。Objective： To observe the efficacy and complications of γ-knife radiotherpy for advanced non-small cell lung cancer. Methods： 216 patients with advanced NSCLC were treated with 8 to 12 times body gamma-knife radiotherapy within 2 weeks. The dose at 50% isodose line of PTV, the dose at 70% to 80% isodose line of CTV and the maximum dose at tumor center were 50Gy, 70Gy and 80Gy - 100Gy respectively. The 50% - 80% isodose line of prescription dose covered more than 95% volume of FIT. The median follow-up duration was 21months. Results： Three to six months after treament, the complete response rate was 28. 2%, and the overall response rate was 80. 3%. The incidence of radiation pneumonia and esophagitis were 21.9% （47/216） and 6. 25% （13/216） respectively. Conclusion： The stereotactic radiotherapy may can effectively improve the local control of the non- small cell lung cancer with low incidence of complication.

关 键 词：非小细胞肺癌 伽玛刀 立体定向放射治疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]