细胞因子水平与肝硬化患者预后相关性研究  

Study on the Relationship between Serum Levels of Cytokines and Prognosis of Patients with Liver Cirrhosis

作　　者：朱励[1] 郭花[1] 达炜[1] 王龙[1] 孙群[1] 朱金水[1] 

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《中国临床医学》2008年第2期179-180,共2页Chinese Journal of Clinical Medicine

基　　金：上海市重大医学课题基金(编号99ZDI001)

摘　　要：目的:探讨血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、白细胞介素10(IL-10)水平与肝硬化患者预后之间的关系。方法:采用ELISA法分别测定肝硬化患者治疗前后的IL-6、IL-8、IL-10水平。结果:肝硬化患者的IL-6、IL-8水平较正常对照组显著升高、IL-10水平则较正常对照组显著降低。采用口服氧化苦生碱治疗一疗程后肝功能减退组的IL-6、IL-8水平较治疗前有显著降低,IL-10水平升高,但无显著差异,而肝功能恢复组的IL-6、IL-8水平较治疗前显著降低,IL-10水平则显著升高。结论:IL-6、IL-8、IL-10与肝硬化患者预后有关,其血清水平可作为判断肝硬化患者预后的指标之一,氧化苦生碱可能具有一定抗肝硬化作用。Objective：To study the relationship between serum levels of cytokines and the treatment and prognosis of patients with liver cirrhosis. Methods：60 patients with liver cirrhosis were divided into two groups, hepatic functions of 34 patients were aggravated and 26 cases were restored or near to normal levels after oral matrine therapy for three months, serum levels of IL- 6, IL-8, IL-10 were measured by ELISA methods in all these patients before and after therapy and 60 healthy subjects, respectily. Results： The serum levels of IL-6, IL-8, IL-10 in patients with liver cirrhosis were significantly higher than healthy subjects. The serum levels of IL-6,IL-8 in aggravated hepatic function group after therapy were lower than that of patients with liver cirrhosis before the therapy（131.8 ＋ 16.8 vs 70.3 ＋ 24.8,147.3 ＋ 17.9 vs 72.3 ＋ 8.2, P〈0.01） while the serum level of IL-10 was lower than healthy subjects（20.4 ＋ 3.1 vs 110.3 ＋ 15.8,P〈0.01）. in aggravated hepatic function group, serum levels of IL-6 ,IL-8 after therapy were no obvious different compared with before therapy（ 110.0 ＋ 14.6 vs 131.0 ＋ 16.5,126.8 ＋ 12.6 vs 130.3 ＋ 16.4 g/l,P〉0. 05） ,but the serum level of IL-10 was significantly higher than that before therapy （ 90.3 ＋ 3.5 vs 65.4 ＋ 2.5 g/l, P〈0.01 ）, in restored hepatic function group, serum levels of IL-6,IL-8 after therapy were significantly decreased（56.0 ＋ 5.76 vs 129.0 ＋ 13.5,68.8 ＋ 2.46 vs 129.3 ＋ 113.6 μ/l, P〈0.05）, while the serum level of IL-10 was were significantly higher（278.3 ＋ 28.5 vs 115.411.5, P〈0.01 ）, the serum levels of HA,LN, IV C after therapy in patients with hepatic cirrhosis were markedly lower than that of these patients before therapy（147.3 ＋ 7.82 vs 90.2 ＋ 4. 18,162. 1 ＋ 8.41 vs 67.3 ＋ 5.24 and 427. 1 ＋ 16.2 vs 213. 1 ＋ 8. 10 ,P〈0.01）. Conclusion：Serum levels of cytokines may be correlated with the treatment and prognosis of patients with liver cirrhosis, they may be taken as one of ma

关 键 词：细胞因子 肝硬化 酶联免疫法 氧化苦参碱 

分 类 号：R575.2[医药卫生—消化系统]