人乳头瘤病毒感染与非吸烟女性肺癌关系  

Relationship between HPV infection and lung cancer in nonsmoking female

作　　者：李雪莲[1] 关鹏[1] 尹智华[1] 白维君[2] 崔泽实[3] 周宝森[1] 

机构地区：[1]中国医科大学流行病学教研室,沈阳110001 [2]辽宁省肿瘤医院 [3]中国医科大学实验技术中心

出　　处：《中国公共卫生》2008年第5期513-515,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(30471493);美国中华医学基金(00-726)

摘　　要：目的探讨人乳头瘤病毒(HPV)感染与非吸烟女性肺癌的相关性,以及HPV感染对脆性组氨酸三联体(FHIT)基因杂合性丢失的影响。方法采用1∶1匹配的病例对照研究方法,应用PCR技术检测肺癌组织与对照组织中HPV-DNA相关序列,同时检测FHIT基因杂合性丢失状况。结果肺癌组织HPV-E6检出率高于对照组,OR=3.500,高危型HPV感染肺组织中FHIT基因杂合子丢失率较高。同时HPV感染与口服避孕药的使用、烹调油烟暴露及既往肺部疾病史间存在交互作用。结论高危型HPV感染与女性肺癌的发生有关,HPV感染引发的肺癌可能与基因整合使FHIT基因杂合性丢失有关,同时与口服避孕药的使用、烹调油烟暴露及既往肺部疾病史等存在协同效应。Objective To explore the relation between HPV infection and lung cancer in female nonsmoker, and to investigate its relationship with LOH of FHIT gene. Methods Lung cancer specimens and control specimens were examined for the sequences of nucleotide markers for FHIT gene and fragment of HPV-DNA by PCR. Results HPV E6 had a higher prevalence in cancer tissue than that in normal tissues, OR = 3. 500. In all 19 cases of HPV infection, there were 15 cases in which the FHIT gene LOH was found, more than that of non-infection. HPV infection interacted with some lung cancer risk factors. Conclusion t-IPV infection contribues to lung cancer in nonsmoking female. LOH of FHIT gene might be involved in carcinogenesis of HPV related lung cancer, and has cooperative effect with other risk factors.

关 键 词：人乳头瘤病毒 FHIT基因 女性肺癌 

分 类 号：R734.2[医药卫生—肿瘤]