MMP-9、TIMP-1在不明原因不孕症子宫内膜的表达  

Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in human endometrium of unexplained infertility

作　　者：张丽[1] 国宏莉[1] 田林[1] 曹书芬[1] 杜兴贵[1] 

机构地区：[1]郧阳医学院附属人民医院病理科,湖北郧阳442000

出　　处：《西部医学》2008年第3期501-503,共3页Medical Journal of West China

摘　　要：目的检测不明原因不孕妇女子宫内膜、正常子宫内膜中MMP-9及其抑制剂TIMP-1的表达,探讨不明原因不孕的发病机制。方法采用免疫组化S-P法检测30例不明原因不孕子宫内膜组织及20例正常子宫内膜组织中MMP-9、TIMP-1的表达水平。结果MMP-9、TIMP-1在正常子宫内膜腺上皮和基质细胞均见不同程度的表达,增生期表达水平低,分泌期表达水平显著增强,差异有显著性。而二者在不明原因不孕组子宫内膜的表达水平显著减低,与正常组相比,差异有显著性。结论MMP-9、TIMP-1在不明原因不孕妇女的低水平表达,可能会引起子宫内膜容受性的降低,从而使着床失败,导致不孕。Objective To study the expression of matrix metalloproteinase-9 （MMP-9） and tissue inhibitor of metalloproteinase-1 protein（TIMP-1） in cycling endometrium with unexplained infertility and normal endometrium,and to explore the relationship between the expression of MMP-9, TIMP-1 in unexplained infertility and normal pregnancy. Methods Immunohistochemistry （S-P technique） was used to detect the expression of MMP-9 and TIMP-1 in endometrium of selected cases consisting of 30 unexplained infertility and 20 normal endometrium. Results The expression of MMP-9 and TIMP-1 in normal endometrium could be observed in glandular epithelium and stromal cells during different phase. They expressed low in proliferative phase ,but obviously higher in secretory phase ,which showed significant difference in statistics （P〈 0. 05）. But in unexplained infertility their weak expression was noted during proliferative phase and secretory phase. Between the expression levels of infertility and normal endometrium, the difference was significant（P〈0. 05）. Conclusion The weak expression of MMP-9 and TIMP-1 will reduce the potential of endometrial acceptation and embryo implantation, and accordingly may bring about infertility.

关 键 词：不明原因不孕 MMP-9 TIMP-1 子宫内膜 胚胎植入 

分 类 号：R711.6[医药卫生—妇产科学]