支气管镜引导植入^125I粒子治疗中央型非小细胞肺癌  

Application of ^125I iodine brachytherapy seeds implantation guided by flexible fiber-optic bronchoscopy image-in terminal central non-small cell lung carcinoma

作　　者：李小东[1] 郭永涛[2] 张遵城[2] 董华[2] 王梦义[3] 柴树德[4] 郑广钧[4] 冯仲苏[1] 

机构地区：[1]天津医科大学第二医院放疗科,300211 [2]天津医科大学第二医院核医学科,300211 [3]天津医科大学第二医院呼吸科,300211 [4]天津医科大学第二医院胸心外科,300211

出　　处：《中华全科医师杂志》2008年第5期313-316,共4页Chinese Journal of General Practitioners

摘　　要：目的分析研究纤维支气管镜影像引导^125I粒子植入治疗晚期中央型非小细胞肺癌的疗效。方法对确诊的66例晚期非小细胞肺癌患者制定系统放疗计划，通过纤维支气管镜影像引导植入放射性^125I粒子，并行剂量学验证和定期复查随访。结果随访1年时，治疗组中完全缓解15例，部分缓解36例，有效率77．3％，1年生存率80．3％；随访2年时，治疗组中完全缓解7例，部分缓解22例，稳定3例，无疾病进展1例，有效率90．6％，2年生存率是43．8％。无早晚期放射损伤发生。结论支气管镜引导植入^125I粒子疗法能够较好地解除气道梗阻，对支气管肺癌具有明显的控制疗效。Objective To analyze therapeutic efficiency of ^125I iodine brachytherapy seeds implantation guided by flexible fiber-optic bronchoscopy （FFB） image in terminal central non-small cell lung carcinoma （NSCLC）. Methods Under therapy planning system （TPS） and guided by flexible fiber-optic bronchoscopy image, ^125I iodine seeds were implanted in 66 confirmed terminal cases with NSCLC and its posology was validated and rechecked regularly. Results Complete remission （CR） was observed in 15 cases and partial remission （PR） in 36 cases during the first-year follow-up, with an overall efficiency rate （CR ＋ PR） of 77.3 percent and one-year survival of 80. 3 percent. Complete remission （CR） was observed in seven cases, partial remission （PR） in 22 cases, stable condition （SC） in three cases, and no progression was found during the second-year follow-up, respectively, with an overall efficiency rate （CR ＋ PR） of 90. 6 percent and two-year survival of 43.8 percent. No radioactive damage were observed in the early and late stages of therapy. Conclusions Therapy with radioactive ^125I iodine seeds implantation guided by flexible fiber-optic bronchoscopy image could relieve airway obstruction effectively in terminal lung cancer and control progression of bronchiogenic carcinoma.

关 键 词：近距离放射疗法 碘 癌 非小细胞肺 

分 类 号：R734.2[医药卫生—肿瘤]