中国首次发作的精神分裂症患者5-HT_(2A)受体基因多态性与阴性症状的关系(英文)  

5-HT_(2A) receptor gene polymorphism and negative symptoms in first episode(drug-naive) Chinese Han nationality individuals with schizophrenia

作　　者：王育红[1] 李文强[2] 黄照[1] 石玉中[2] 王绪轶[1] 黄劲松[1] 周旭辉[1] 谌红献[1] 郝伟[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]新乡医学院第二附属医院,河南新乡453002

出　　处：《中南大学学报（医学版）》2008年第4期293-298,共6页Journal of Central South University ：Medical Science

基　　金：National Natural Science Foundation of China(30370522,30500180);Science and Technology Foundation of Henan Province of P.R.China(0424410045)

摘　　要：目的:研究5-HT2A受体T102C基因多态性是否与首次发作的中国精神分裂症患者症状严重程度以及阴性症状相关。方法:201名首次发作的中国精神分裂症患者入组。运用PCR-RFLP技术鉴定5-HT2A受体基因T102C基因型,PANSS量表评估药物治疗前精神症状严重程度。结果:5-HT2A受体102-T/T基因型与治疗前PANSS总基线分和阴性症状分量表分显著相关,但是与阳性症状和一般精神病理症状量表分无相关性。结论:5-HT2A受体T102C基因功能多态性可能在中国汉族精神分裂症阴性症状和预后中起一定作用。Objective To investigate whether the 5-hydroxytryptamine 2A receptor （5-HT2A） gene T102 C polymorphism is associated with the severity symptoms and negative symptoms in the first episode Chinese Han nationality patients with schizophrenia. Methods Altogether 201 first episode Chinese Han nationality patients with schizophrenia were enrolled in this study. Genotyping of 5-HT2A gene T102C polymorphism was performed by PCR-RFLP technique. The positive and negative Symptom Scale （ PANSS ） was used for the evaluation of the severity of psychotic symptoms before any drug treatment. Results 5-HT2A receptor 102-T/T genotype was significantly associated with both the PANSS total and negative symptom subscale baseline scores before the treatment, but not with the positive and general psychopathology subscales. Conclusion 5-HT2A T102 C functional polymorphism may play a role in negative symptoms and prognosis of Chinese Han nationality people with schizophrenia.

关 键 词：精神分裂症 5-HT24受体 基因多态性 阴性症状 汉族 中国人 

分 类 号：R749.3[医药卫生—神经病学与精神病学]