鲍文氏病和鲍文样丘疹病的临床病理及免疫组化研究  

Study on the clinical pathological and immunohistochemistry features of Bowen'disease and Bowenoid papulosis in vulvae

作　　者：孙梅[1] 杨隆茵[2] 杨华[3] 

机构地区：[1]吉林大学第二医院病理科,吉林长春130041 [2]吉林省白山市中心医院病理科 [3]吉林大学第二医院麻醉科

出　　处：《中国妇幼保健》2008年第15期2127-2129,共3页Maternal and Child Health Care of China

摘　　要：目的:研究外阴鲍文氏病和鲍文样丘疹病的免疫组化和病理形态学特征。方法:对发生在外阴的39例鲍文氏病、34例鲍文样丘疹病和32例鳞状细胞癌进行免疫组化染色和病理形态学分析。结果:鲍文氏病属于原位癌而鲍文样丘疹病可视为良性病变。p27在鲍文样丘疹病中的表达明显高于在鲍文氏病和鳞状细胞癌中的表达(P<0.01)。Ki 67在鳞状细胞癌中的表达明显高于鲍文氏病和鲍文样丘疹病(P<0.05)。结论:通过免疫组化可以评估鲍文氏病和鲍文样丘疹病的恶性潜能,并有助于临床的诊断和治疗。Objective： To investigate the clinical pathology and immunohistochemistry features of Bowentlisease and Bowenoid pap- ulosis in vulvae. Methods： Immunohistochemistry staining and pathological analysis was performed for 39 Bowenitisease, 34 Bowenoid papulosis and 32 squamous carcinoma in vulvae. Results： Bowen＇disease was an in situ carcinoma but Bowenoid papulosis was a benign disease. The expressions of p27 were significantly higher in Bowenoid papulosis than that in Bowentlisease and in squamous carcinomas （ P 〈 0. 01 ） . Ki 67 expressions increased significantly in squamous carcinoma than that in Bowentlisease and in Bowenoid papulosis. Conclusion： The potential malignance of Bowentlisease and Bowenoid papulosis are evaluated by means of immunohistochemistry that is helpful for clinical diagnoses and treatments.

关 键 词：鲍文氏病 鲍文样丘疹病 免疫组化 

分 类 号：R737[医药卫生—肿瘤]