非小细胞肺癌组织中p33^(ING1)蛋白的表达及临床意义  

Expression and its clinical significance of p33^(ING1) in non-small cell lung carcinoma

作　　者：曾凡军[1] 丁文柏[1] 陈世雄[1] 徐新娟[1] 周媛媛[1] 罗代珍[1] 夏道奎[1] 张春芳[1] 

机构地区：[1]三峡大学第一临床医学院.宜昌市中心人民医院呼吸内科,宜昌443003

出　　处：《陕西医学杂志》2008年第5期577-579,共3页Shaanxi Medical Journal

摘　　要：目的:研究p33ING1在非小细胞肺癌(NSCLC)中的表达及其与临床病理特征的关系;探讨p33ING1在NSCLC发生、发展中的可能作用机制。方法:用免疫组化SP法检测p33ING1在40例NSCLC和10例正常肺组织中的表达。结果:p33ING1在NSCLC组织中阳性率(57.5%,23/40)低于正常肺组织(100.0%,10/10),两组有显著性差异(P<0.05)。p33ING1低表达与肺癌的分化程度、TNM分期及淋巴结转移均有关:p33ING1在无淋巴结转移组及淋巴结转移组癌组织中的阳性表达率分别为76.2%(16/21)、36.8%(7/19),两组有显著性差异(P<0.05);在UICC的TNM分期~期、~期组病例中分别为69.0%(20/29)、27.3%(3/11)(P<0.05);在高、中、低分化组病例中分别为87.5%(7/8)、66.7%(12/18)和14.3%(2/14),其中高、低分化组间及中、低分化组间的阳性表达率均具有极显著差异(P<0.01)。p33ING1的表达与其他临床病理参数(患者性别、年龄、病理组织学类型等)不相关(P>0.05)。结论:p33ING1在NSCLC中低表达,它的低表达对判断NSCLC恶性程度、浸润甚至转移有重要价值。p33ING1蛋白的低表达在NSCLC的发生发展中可能起重要作用。Objective： To investigate the expression of p33^ING11 and its relationship with clinicopathology feature in non-small cell lung carcinoma （NSCLC）; and to explore possible mechanism of p33^ING1 in the oncogenesis of NSCLC. Methods： Immunohistochemistry （labeled streptavidin-biotin method） was used to detect p33^ING1 expression in 40 cases with NSCLC and 10 cases with normal lung tissues. Results： The positive rates of p33^ING1 in 40 cases with NSCLC （57.5% 23/40） were significantly lower than those with normal lung tissues （100. 0%, 10/10） （P〈0. 05）. The down- regulation of the expression of p33^ING1 was related to differentiation and TNM stages and lymph node metastases. The positive rates of p33^ING1 expression were 76.2% （16/21） and 36, 8% （7/19） in cancerous tissues with or without lymph node metastasis （P〈0. 05）; the positive rates of p33^ING1 expression in cancerous tissue at UICC TNM Ⅰ - Ⅱ stages were significant higher than those at Ⅲ -Ⅳstages [69.0% （20/29） vs 27.3% （3/11） （P〈0.05）1; the positive rates of p33^ING1 were 87. 5N （7/8）, 66. 7% （12/18） and 14. 3% （2/14） in well-differentiated, moderately differentiated and poorly differentiated tissues, respectively; among which the positive rates of well-differentiated and moderately differentiated tissues were significantly higher than those in poorly differentiated tissues （P〈 0. 01）. The expression of p33^ING1 protein was not associated with other clinicopathological characteristics such as sex, age, pathohistological types, etc. （P〉0. 05）. Conclusion：Expression of p33l^ING1 was reduced in NSCLC. Downexpression of p33^ING1 was useful for evaluating malignancy degree and invasion and metastasis of NSCLC. Downexpression of p33^ING1 might play an important role in the oncogenesis of NSCLC.

关 键 词：癌 非小细胞肺 病理学 基因 肿瘤抑制 代谢 

分 类 号：R735.705[医药卫生—肿瘤] R734.2[医药卫生—临床医学]