肺癌组织中幽门螺杆菌感染情况的实验研究  

Experimental study on the Helicobacter pylori infection in lung cancer

作　　者：李翠梅[1] 丁焕然[1] 韩光亮[2] 

机构地区：[1]华北煤炭医学院附属医院胸外科,唐山063000 [2]中国医学科学院药物研究所

出　　处：《陕西医学杂志》2008年第5期607-608,619,共3页Shaanxi Medical Journal

基　　金：唐山市科技局研究与发展指导计划(07134616c)

摘　　要：目的:探讨肺癌组织中幽门螺杆菌(HP)的感染情况及其与肺癌的关系。方法:以HP阳性的胃组织为阳性对照,用免疫组化的方法对手术切除石蜡包埋的38例肺癌组织及8例癌旁正常肺组织中的HP进行检测,并采用图像分析法进行形态学定量。结果:肺癌及癌旁组织中HP的感染率分别为89.5%和87.5%,肺癌及其癌旁组织中HP的积分光密度分别为13.07和9.11,两组无显著性差异(P>0.05),但肺癌组织中HP的平均面积高于癌旁组织,两组有显著性差异(P<0.05),HP感染与患者的性别、癌组织的分化程度、组织类型以及有无淋巴结转移之间均无显著性差异(P>0.05)。结论:肺癌组织中存在较高的HP感染率,对肺组织细胞的恶性转化可能有一定作用。Objective： To study the Helicobacter pylori （HP） infection in lung cancer and the relationship between HP infection and lung cancer. Methods：38 cases of lung cancer tissues and 8 cases of peripheral lung tissues were used to detect HP infection by immunohistochemistry, while HP positive gastric tissue was served as positive control, Results：The positive rate of HP infection in lung cancer and peripheral lung tissues were 89.5% and 87.5% respectively. No relationship was found among HP infection, sex, clinichistopathological type, differentiation of cancer and lymph node metastasis. The average area（A. A）of HP and integral optical density （IOD） in lung cancer tissues were higher than those in peripheral lung tissues. Conclusion ：The infection of HP in lung cancer was higher and might be correlative to lung cancer.

关 键 词：肺肿瘤/病理学 幽门螺杆菌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤] R573.1[医药卫生—临床医学]