高强度聚焦超声治疗及控制兔肝VX2肿瘤发展的实验研究  

High Intensity Focused Ultrasound for Treatment of VX2 Rabbit Liver Tumors and Metastatic Control:An Experimental Study

作　　者：李秋洋[1] 周晓东[1] 罗文[1] 何光彬[1] 于铭[1] 韩增辉[1] 秦海英[1] 

机构地区：[1]解放军第四军医大学西京医院超声诊断科,西安市710032

出　　处：《中国超声医学杂志》2008年第5期395-398,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金(No.30570489)

摘　　要：目的探讨高强度聚焦超声(HIFU)治疗及控制肝肿瘤发展转移的效果。方法采用兔肝VX2肿瘤模型进行HIFU辐照。辐照后不同时期处死动物以观察其病理变化。另以辐照组及对照组动物各8只,于2周后处死,比较肿瘤生长及肺转移的情况。结果HIFU辐照后肿瘤细胞立即发生凝固性坏死,电镜下亦见到不可逆的破坏。2周后有6只动物的肿瘤原发灶已被完全破坏;另2只靶区外有少量肿瘤残存,其体积为59.8mm3和10.4mm3,而对照组的肿瘤平均体积为(1571.1±349.7)mm3。辐照组有2只(25%)发生肺转移,转移结节数为10和3;对照组全部发生肺转移,转移结节数为54±30。两组差异有显著性。结论HIFU对兔肝VX2肿瘤有很强的杀伤作用,对控制肿瘤的发展及转移有一定的疗效。Objective To investigate the effectiveness of high intensity focused ultrasound （HIFU） on the treatment of liver tumors and the control of tumor metastasis. Methods Sixteen New Zealand rabbits bearing VX2 liver tumors were irradiated with HIFU at an intensity of 0-3 000 W/cm^2. Eight other tumor bearing rabbits served as the controls. The treated rabbits were sacrificed at different periods after irradiation to observe the pathological changes. Eight of the treatment group and the control group were killed on the 14th day to study the growing condition of the primary tumors and the status of lung metastasis. Results Tumor cells revealed coagulation necrosis immediately after irradiation with HIFU. Irreversible destruction was observed under electron microscope. The primary tumors in six rabbits of the treatment group were been completely eradicated ; while in the other two, tumor residua was found outside the target area. The size of the tumor residua was 59.8 mm^3and 10.4 mm^3in each while the average size of the primary tumors in the control group was 1571.1-4- 350. 7 mm^3. Lung metastasis took place in 2 rabbits in the treatment group, with 10 and 3 metastatic nodules, respectively. Lung metastasis occured in all the control animals. The number of metastatic nodules was 54-4-30. The difference between these two groups was significant. Conclusions HIFU wound be effective on the treatment of liver tumors and on the control of tumor metastasis.

关 键 词：肝肿瘤 HIFU 动物实验 

分 类 号：R735.7[医药卫生—肿瘤]