盐酸曲马多包衣缓释片的制备及体外释药行为  

Preparation and in vitro characterization of tramadol hydrochloride sustained-release tablets

作　　者：周桂荣[1] 李云立[1] 刘福利[1] 陈玉洁[1] 梁亚莉[1] 

机构地区：[1]石药集团中奇制药技术(石家庄)有限公司,河北石家庄050051

出　　处：《沈阳药科大学学报》2008年第5期352-355,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备盐酸曲马多缓释片,考察盐酸曲马多缓释片体外释放度,探讨其体外释放机制。方法片芯以亲水凝胶和疏水阻滞剂组成,运用正交试验确定片芯处方,以醋酸纤维素(CA)、聚乙二醇1500为包衣液包衣,药片打孔,得到盐酸曲马多包衣缓释片。结果经拟合,释放过程符合一级动力学过程。结论该缓释片处方合理,工艺简单,产品稳定。Objective To prepare tramadol hydrochloride sustained-release tablets and study the in vitro release characteristics of the tramadol hydrochloride sustained-release tablets. Methods The tablet core composed of hydrophilic gum and hydrophobic blocker. The optimal formulation of the tablet core was obtained by employing orthogonal design. Tablets were coated with the solution which was prepared by cellulose acetate （CA） and polyethylene glycol 1500. The pore was made on either side of tablet. Results The release pattern met the need required in Chinese Pharmacopoeia （2005）. The profile of accumulative release accorded with first order kinetics. Conclusions The formulation of the sustained-release tablets is rational and simple, and the releases of different batches are uniform and stable.

关 键 词：盐酸曲马多 缓释片 体外释放度 

分 类 号：R730.53[医药卫生—肿瘤] R971.1[医药卫生—临床医学]