系统生物学方法在中医药研究中的运用  

Application of systems biology method in the research of traditional Chinese medicine

作　　者：李平[1] 杨丽平[1] 

机构地区：[1]中日友好医院临床医学研究所,北京100029

出　　处：《中西医结合学报》2008年第5期454-457,共4页Journal of Chinese Integrative Medicine

基　　金：国家重点基础研究发展计划(973计划)(No2005CB523503);国际科技合作计划(No2006DFB31480)

摘　　要：系统生物学作为21世纪的一门新兴科学,其研究方法和研究思路与传统的中医学有很多相似之处。运用系统生物学方法有助于揭示中医证候的科学内涵和开展中药现代化研究。系统生物学的技术平台为组学,其中蛋白质组学为明确中医证候的本质和中药复方的作用提供了实验方法;相对于基因组学以及蛋白质组学等分子生物学手段来说,代谢组学更加直接、快速和简便,特别是为中医药防治肾脏疾病的研究提供了有效的方法。Systems biology is a new science of the 21st century, which resembles traditional Chinese medicine （TCM） in many aspects such as study method and design. Adoption of systems biology approach would do much help for exploring the scientific connotation of TCM syndrome and the modernization of Chinese herbal medicine. Its technological platforms, such as genomics, proteomics and metabonomics, provide powerful tools for the study of the essence of TCM syndrome and the function of herbal compound recipe. Compared with other molecular biological methods, such as genomics and proteomics, metabonomics method is more direct and more concise, especially for providing an effective method for the study of TCM therapy in preventing and treating kidney diseases.

关 键 词：系统生物学 证候 中医现代化 蛋白质组学 

分 类 号：R2-03[医药卫生—中医学]