重症肝炎患者肠道屏障功能的变化  

The changes of barrier of gut in severe hepatitis

作　　者：刘冬妍[1] 鲁学恒[2] 刘沛[3] 

机构地区：[1]中国医科大学附属盛京医院实验研究中心,沈阳110004 [2]沈阳医学院沈洲医院 [3]中国医科大学第一附属医院传染科

出　　处：《中国综合临床》2008年第5期412-414,共3页Clinical Medicine of China

基　　金：国家自然基金资助项目（30670947）;辽宁省教委课题资助项目（05L466）

摘　　要：目的研究重症肝炎患者肠道IgA、分泌片（SC）和ZO-1、occludin的变化，了解重症肝炎患者伴发腹部症状的原因。方法采用免疫组化方法分别检测肠道IgA、SC和ZO-1、occludin。结果与对照组比较，重症肝炎患者肠道IgA、SC和ZO-1、occludin染色明显减弱。结论重症肝炎患者肠道IgA、SC和ZO-1、occludin表达下降，导致肠道屏障功能发生异常是引起腹部症状的原由之一。Objective To study the changes of IgA,secretory component（ SC） and ZO-1 ,occludin of gut in severe hepatitis and to understand the reason of abdomen symptom in severe hepatitis patients. Methods IgA,SC, ZO-1 and occludin of gut were assayed by immunohistochemistry. Results Compared with the controls,the staining of IgA, SC, ZO-1 and occludin in severe hepatitis were notably decreased. Conclusion In severe hepatitis, IgA, SC, ZO-1 and occludin expression of gut decrease, leading to the abnormality of barrier of gut, which is one the reasons of resultings in abdomen symptoms in severe hepatitis.

关 键 词：肝炎 肠道屏障 IGA 分泌片 ZO-1 OCCLUDIN 

分 类 号：R575.1[医药卫生—消化系统]