前列腺体积与前列腺特异抗原及抗原密度关系的多元回归研究  

Stady of Multiple Regression and Correlation in the Prostate Volume,Prostate Specific Antigen and Prostate Specific Antigen Density

作　　者：周建奖 李家富[1,2] 陈娅 润丹[1,2] 

机构地区：[1]贵州省肿瘤研究所 [2]贵阳医学院附院泌尿外科

出　　处：《贵阳医学院学报》1997年第4期347-349,共3页Journal of Guiyang Medical College

摘　　要：对１００例前列腺增生（ＢＰＨ）患者的前列腺体积、年龄、血清前列腺特异抗原（ＰＳＡ）、抗原密度（ＰＳＡＤ）进行多元回归与相关分析。结果：年龄和前列腺体积均与血清ＰＳＡ浓度显著相关（Ｐ＜０．０１），其中，体积与ＰＳＡ之间和年龄与体积之间具有相关性（Ｐ＜０．００１、Ｐ＜０．０５），而年龄与ＰＳＡ之间无相关性（Ｐ＞０．０５），体积每增加１０ｃｍ３，ＰＳＡ增高０．９μｇ／Ｌ。ＰＳＡＤ不受前列腺体积的影响（Ｐ＞０．０５），有８２％的ＢＰＨ患者在正常范围内，其中２４例ＰＳＡ在４～１０μｇ／Ｌ的患者有１８例ＰＳＡＤ≤０．２。血清ＰＳＡ浓度主要受前列腺体积影响，年龄的影响是通过对体积的影响而间接引起的，ＰＳＡＤ可以消除前列腺体积的影响，在评价ＰＳＡ浓度轻度增高时有更高的特异性。To discuss the influence factors on the prostate specific antigen (PSA) and antigen density (PSAD) and their clinical useful value.Multiple regression and correlation in the prostate volume,age,serum PSA and PSAD of 100 patients with benign prostate hyperplasia (BPH).The age and prostate volume together had correlation with the serum concentrations of PSA (P<001).Among those,there were the correlation between the prostate volume and PSA (P<0001) and the age and prostate volume (P<005).But the age had no correlation with PSA (P>005).The PSAD were not influenced by the prostate volume (P>005).In 24 patients with PSA levels being 4-10 μg/L,18 patients' PSAD were lower than 02.The prostate volune had major influence on PSA.The age only had indirect infulence by the effect on the prostate volume.The PSAD may eliminated the influence of the prostate volume on PSA and had more specificity as the serum PSA levels being light increased.

关 键 词：前列腺特异抗原 前列腺体积 PSA 多元回归分析 

分 类 号：R737.25[医药卫生—肿瘤]