齐拉西酮和利培酮治疗精神分裂症的对照研究  

Comparative study on ziprasidone and risperidone in the treatment of schizophrenia patients

作　　者：刘秀清[1] 贾继敏[1] 

机构地区：[1]滨州市人民医院精神卫生中心,滨州市256610

出　　处：《滨州医学院学报》2008年第2期119-120,共2页Journal of Binzhou Medical University

摘　　要：目的比较齐拉西酮和利培酮对精神分裂症的疗效和副作用。方法将符合入组标准的精神分裂症患者随机分为齐拉西酮组和利培酮组,用PANSS和TESS评定疗效和副反应。结果齐拉西酮组总有效率为64.29%,明显高于利培酮组的42.85%。两组在PANSS总分、阴性症状量表分及一般病理症状量表分方面的差异具有显著性(P<0.01)。结论齐拉西酮总体疗效优于利培酮,对阴性症状的效果尤其明显。Objective To compare the clinical effects and side effects of ziprasidone and risperidone in the treatment of schizophrenia.Methods The schizophrenic patients were randomly divided into ziprasidone group and risperidone group.The clinical effects and side effects were observed by the PANSS and TESS.Results The overall efficacy rate of ziprasidone（64.29%） was higher than that of risperidone（42.85%）.There were statistical differences in total score,N and G subscale scores of PANSS between the two groups（P〈0.01）.Conclusion Ziprasidone is superior to risperidone,especially to negative symptoms.

关 键 词：齐拉西酮 利培酮 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]