离子液体双水相萃取分离芦丁的研究  

A Study on the Extraction and Separation of Rutin by Ionic Liquid Aqueous Two-phase System

作　　者：杨青海[1] 那吉[1] 段利平[1] 董学畅[1] 王锐[1] 

机构地区：[1]民族药资源化学国家民委-教育部共建重点实验室,云南昆明650031

出　　处：《云南中医中药杂志》2008年第5期44-45,共2页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：教育部科学技术研究基金重点资助项目(编号:207108)

摘　　要：建立了由亲水性离子液体四氟硼酸1-丁基-3-甲基咪唑（[BMIm]BF4）和（NH4）2SO4形成的双水相体系萃取分离芦丁的新方法。分别研究了盐的浓度、离子液体浓度、芦丁加入量和溶液pH值对芦丁萃取率的影响。结果表明，（NH4）2SO4加入量在1．5g，离子液体加入量在1．5～2．0mL，芦丁加入量在1．0～1．5mL，溶液酸度在pH4～6范围，离子液体双水相体系对芦丁有较高的萃取率（E％〉90％）。A new aqueous two-phase system for the extraction and separation of Rutin,which was formed by a room temperature water-soluble ionic liquid BF4(1-butyl-3-methylimidazolium tetrafluoroborate) and phase-forming salt(NH4)2SO4,was studied and established.The effects of concentrations of ionic liquid,salt,Rutin and the PH value on the extraction efficiency1 were analyzed systematically.The findings showed that the ionic liquid aqueous two-phase system had the highest extraction efficiency(E%>90) with the solution by putting in 1.5g of(NH4)2SO4,1.5~2.0mL of ionic liquid,1.0~2.0mL of rutin,with the range of PH values 4~6.

关 键 词：离子液体 双水相 芦丁 萃取分离 

分 类 号：R284.2[医药卫生—中药学]