兔肾VX2肿瘤的超声造影实验研究  

Contrast-enhanced ultrasonography improves diagnosis of renal VX2 tumor in rabbits

作　　者：沈德娟[1] 杨斌[1] 倪黎登[2] 傅宁华[1] 王江陵[1] 

机构地区：[1]南京大学医学院临床学院 、南京军区南京总医院超声诊断科,江苏南京210002 [2]南京大学医学院临床学院 、南京军区南京总医院普通外科,江苏南京210002

出　　处：《医学研究生学报》2008年第5期491-493,I0005,共4页Journal of Medical Postgraduates

基　　金：南京军区南京总医院科研基金重点资助项目(批准号:2005115)

摘　　要：目的：探讨兔VX2肾肿瘤超声造影的图像特征。方法：12只新西兰兔采用包埋法于右肾植入VX2肿瘤,共12个结节。经外周静脉注射声诺维（SonoVue）,分别于植瘤后7、14、21 d进行超声造影,观察VX2肿瘤大小及其灌注特点。结果：肿瘤最佳干预时间为植入后2-3周,3周后易发生坏死。VX2肾肿瘤超声造影后主要表现为充盈缺损的＂负显影＂,可使肾肿瘤的检出率由造影前的57.1%（12/21）提高至造影后的100%（21/21）。结论：超声造影可明显加强肿瘤血流信号的显示,显著提高VX2肾肿瘤的诊断率。Objective：To evaluate the characteristics of contrast-enhanced ultrasonography in renal VX2 tumors. Methods： VX2 tumors were transplanted into 12 rabbit kidneys and observations were made by contrast-enhanced ultrasonography 7,14 and 21 days after the transplantation respectively. Results： The best intervention time was 2 -3 weeks after the tumor transplantation,while nicrosis was apt to occur after 3 weeks. The visibility of the renal tumors was significantly increased from 57. 1% （ 12/21 ） to 100% （21/21）. Contrast-enhanced uhrasonography showed defect and delineation of VX2 tumors. Conclusion： Contrast-enhanced uhrasonography can improve the peripheral and internal blood flows of the tumors promote the diagnosis of renal tumors.

关 键 词：超声造影 肾肿瘤 VX2 

分 类 号：R730.41[医药卫生—肿瘤]