心理神经免疫学在肿瘤学研究中的进展  

Advances of psychoneuroimmunology in oncology

作　　者：丛昌盛[1] 于甬华[1] 

机构地区：[1]山东省肿瘤医院放疗科,山东济南250117

出　　处：《中华肿瘤防治杂志》2008年第8期635-638,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省卫生厅2005年科技攻关项目(2005H-W138)

摘　　要：目的:总结心理神经免疫学在肿瘤学研究中的新进展。方法:应用pubmed及CNKI期刊全文数据库,以心理神经免疫学、肿瘤学、应激和心理干预为关键词,检索1990-01～2007-10相关肿瘤心理神经免疫学的文献。纳入标准:1)肿瘤心理神经免疫学的研究进展;2)应激的肿瘤心理神经免疫学研究;3)心理干预的肿瘤心理神经免疫学研究。粗选有百余篇关于肿瘤心理神经免疫学方面的文章,根据纳入标准,精选72篇文献,最后纳入分析24篇文献。结果:心理神经免疫学是一门边缘交叉学科,主要研究肿瘤等身心疾病神经系统与免疫系统的相互作用。机体内中枢神经系统和免疫系统通过神经-内分泌免疫网络相互调节。当机体受到不良应激时,可以引起免疫功能下调,特别是淋巴细胞增殖能力的下降,NK细胞数目及毒性的下降,进而影响肿瘤的发生发展,并一定程度上影响肿瘤治疗的疗效。有效的心理行为干预通过调节心理神经免疫网络,对控制肿瘤和提高疗效具有积极的意义。以往肿瘤心理神经免疫学大多研究非特异性免疫反应,而肿瘤特异性T细胞及抗体反应也是未来值得进一步研究的领域。结论:研究心理神经免疫学在肿瘤学中的进展有重要意义,在肿瘤临床治疗中开展心理行为干预有助于提高患者的生活质量及治疗疗效。OBJECTIVE：To review advances of psychoneuro-immunology in Oncology. METHODS： Literatures about psychoneuroimmunology in oncology were retrieve in pubmed and cnki through 1990.1 to 2007.10. The docuterm were ＂Psychoneuroimmunology, Oncology, stress, psychiatric intervention＂, and so on. Retrieval criterion： 1）advances of psychoneuroimmunology in Oncology; 2） stress and psychoneuro-immunology in oncology; 3） psychiatric intervention and psychoneuroimmunology in oncology. Hundreds of literatures related were collected,and 72 were further studied, among which 24 were used. RESULTS： Psychoneuroimmunology is a frontier branch of science to investigate the interaction between nervous system and immune system in psychosomatic diseases. In our body there is one nerve-endocrine-immune network through which central nervous system and immune system will communicate with each other. Stress can down-regulate immune function to induce tumorigenesis and limit curative effect. Effective psychological intervention can reverse such a process in some sense. Most work has been done in nonspecific immune reaction, and our focus should be made more for tumor-specific immune reaction. CONCLUSION： To study advances of psychoneuro-immunology in oncology is important, and psychiatric intervention can help improve people＇s quality of life and curative effect.

关 键 词：心理神经免疫学 肿瘤学 

分 类 号：R73-3[医药卫生—肿瘤]