瘤内注射对甲苯磺酰胺对大鼠肝癌的治疗作用  

Effect of percutaneous para-toluenesulfonamide injection in treatment of hepatocarcinoma in rats

作　　者：李民英[1] 孟辉[1] 周韶璋[1] 李虹义[1] 朱伟良[1] 张积仁[1] 

机构地区：[1]南方医科大学珠江医院肿瘤中心,广东省广州市510282

出　　处：《世界华人消化杂志》2008年第11期1232-1236,共5页World Chinese Journal of Digestology

摘　　要：目的:观察对甲苯磺酰胺(para-toluenesul-fonamide,PTS)瘤内局部注射对大鼠移植性肝癌的治疗作用.方法:制作SD大鼠皮下移植性肿瘤模型,将60只荷瘤大鼠随机分为4组,即PTS组、无水乙醇组、乙酸组和对照组,分别经皮瘤内注射330g/LPTS、无水乙醇、500mL/L乙酸和生理盐水,观察大鼠肿瘤及心肝肺肾等组织病理变化、抑瘤率和生存时间.结果:330g/LPTS、无水乙醇和500mL/L乙酸均致肿瘤坏死,无水乙醇组和乙酸组坏死区内可见残留癌细胞;PTS治疗14d后肿瘤抑瘤率与无水乙醇组比较,差别有统计学意义(74.4%vs52.0%,P<0.05),治疗21d后肿瘤抑瘤率明显高于无水乙醇组和乙酸组,差别有显著性(92.0%vs68.7%,75.9%,P<0.05);PTS组荷瘤大鼠生存时间与无水乙醇组和乙酸组比较,明显延长(55±4.2dvs45±3.2d,46±2.2d,P<0.05).结论:330g/LPTS用于局部注射治疗大鼠移植性肝癌,肿瘤消融效果优于无水乙醇和500mL/L乙酸.AIM： To investigate the therapeutic effects of percutaneous para-toluenesulfonamide （PTS） injection on hepatocarcinoma in rats. METHODS： Rat models with subcutaneous transplanted hepatocarcinoma were made, and then 60 tumor-bearing rats were randomly divided into 4 groups, subcutaneously injected with 330 g/L PTS, absolute alcohol, 500 mL/L acetic acid and normal saline, respectively. The pathological changes in tumor, heart, liver, lung and kidney tissues were observed, and tumor inhibition rate and survival time of tumor-bearing rats were compared between groups. RESULTS： PTS, absolute alcohol and acetic acid caused the necrosis of cancer cells, but there were residual cancer cells in the necrosis areas of both absolute alcohol group and acetic acid group. On the 14th day after treatment in the PTS group, the tumor inhibition rate was higher than that in the absolute alcohol group （74.4% vs52.0%, P 〈 0.05）, and on the 21st day it was significantly higher than that in the absolute alcohol group or acetic acid group （92.0% vs 68.7%, 75.9%, P 〈 0.05）. The mean survival time in the PTS group was significantly longer than that in the alcohol group or acetic acid group （55 ± 4.2 d vs 45 ± 3.2 d, 46 ± 2.2 d, P 〈 0.05）. CONCLUSION： Local injection of PTS at a concentration of 330 g/L has better effect in the treatment of hepatocarcinoma than absolute alcohol and 500 mL/L acetic acid in rats.

关 键 词：肝细胞性肝癌 治疗 对甲苯磺酰胺 无水乙醇 乙酸 

分 类 号：R735.7[医药卫生—肿瘤]