老年晚期非小细胞肺癌预后的影响因素分析  

Factors Prognostic of Advanced Non-Small-Cell Lung Cancers in the Elderly

作　　者：彭晋[1,2] 吴海鹰[1,2] 张力[1,2] 黄河[1,2] 戴文清[1,2] 胡晓晔[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心内科,广东广州510060

出　　处：《广州医学院学报》2007年第5期48-52,共5页Academic Journal of Guangzhou Medical College

摘　　要：目的:研究对老年晚期肺癌预后的影响因素。方法:回顾性分析2000年1月-2006年6月中山大学肿瘤防治中心内科接受一线化疗的年龄≥70岁的晚期肺癌(IIIb或IV期)患者共99例,总结其临床资料、实验室检查并随访其生存情况。结果:99例老年晚期非小细胞肺癌患者中位生存期:10.0月[95%置信区间:(6.7,13.3)月],1年生存率:41.2%,对临床特点、实验室检查、治疗模式等共15个可能预后因素进行单因素分析,显示:临床分期、体重下降、PS评分、肝转移、乳酸脱氢酶(LDH)、血红蛋白水平(Hgb)、伴随疾病与预后相关。多因素分析显示:PS评分>1、LDH升高、血红蛋白<110g/L、肝转移是老年晚期非小细胞肺癌的不良预后因素。结论:PS评分、LDH、血红蛋白水平和肝转移可能是老年晚期非小细胞肺癌患者的独立预后因素。Objective：To identify factors prognostic of advanced non-small-cell lung cancers （NSCLCs） in the elderly. Methods： We retrospectively reviewed 99 patients （aged 70 years old or above） with advanced NSCLCs （stage Ⅲb or Ⅳ ） who received first-line chemotherapy at the Department of Medical Oncology, Sun Yat-Sen University Cancer Center, between January 2000 and July 2006. Data on their clinical features, laboratory findings and survival at follow-up were evaluated. Results： Of all 99 patients, the median length of survival was 10.0 months （95% confidence interval, 6.6 to 13.3 months） and the one-year survival rate was 41.2%. Univariate analysis including 15 potential factors revealed that clinical stages, weight loss, PS score, liver metastasis, LDH, level of hemoglobin （ Hgb）, comorbidity correlated significantly with the survival. In multivariate analysis, PS score 〉 1, elevated LDH, Hgb 〈 110g/L and liver metastasis were factors significantly unfavorable for prognosis in elderly NSCLC. Conclusion： PS score, LDH, Hgb and liver metastasis may be independent factors prognostic of advanced non-small-cell lung cancer in the elderly.

关 键 词：老年 非小细胞肺癌 生存 预后 

分 类 号：R734.2[医药卫生—肿瘤]