Regulation of interferon production and innate antiviral immunity through translational control of IRF-7  

作　　者：Andrea K Erickson Michael Gale Jr 

机构地区：[1]Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75235-9840, USA [2]Department of lmmunology, University of Washington School of Medicine, Seattle, WA, 98195-7650, USA

出　　处：《Cell Research》2008年第4期433-435,共3页细胞研究（英文版）

摘　　要：Innate intracellular immune programs mediate our first line of defense against virus infection and are dependent on type I interferon （IFNs） [1]. IFNs are cytokines that are produced and secreted from virus-infected cells. Autocrine and paracrine engagement by IFNs of the type I IFN receptor initiates tissue-wide and systemic signaling through the cellular Jak-STAT pathway to induce the transcription of hundreds of interferon-stimulated genes （ISGs） （Figure 1A）. ISG products confer a variety of functions, including direct antiviral activity, immunomodulatory function, and metabolic control to limit virus infection and promote the adaptive immune resoonse.

关 键 词：医学免疫学 抗病毒性 细胞内免疫 IRF-7 

分 类 号：R392[医药卫生—免疫学]