三氯羟苯醚-共聚体牙膏对牙菌斑、牙龈炎的临床效果观察  

Efficacy of a Triclosan/Copolymer Dentifrice in the Control of Plaque and Gingivitis: A Sixmonth Study in China

作　　者：胡德渝[1] 章锦才[1] 万呼春[1] 童冠雄[1] 范旭[1] 李雪[1] 魏建华[1] Zhang Yunpo Anthony R. Volpe Magaret E.Pettone Willianm De Viaio 

机构地区：[1]华西医科大学口腔医学院 [2]美国高露洁公司

出　　处：《华西口腔医学杂志》1997年第4期333-335,共3页West China Journal of Stomatology

摘　　要：本研究的目的是证实含０．３％三氯羟苯醚，２．０％ＰＶＭ／ＭＡ及０．２４３％氟化钠以二氧化硅磨料牙膏在减少菌斑积聚和牙龈炎形成方面对中国成年人群的效果。１５３名健康男女分为实验组及对照组，用双盲法评价６月后临床效果。采用纳入和排除的评价标准后进行了基线检查，实验对象每日使用分配的牙膏和软毛牙刷早晚刷牙一次，３个月和６个月再次检查。检查结果表明，使用含有三氯羟苯醚－共聚体牙膏组与使用不含该成分的对照组相比，实验对象的牙菌斑、牙龈炎指数分别减少１６．１％及２４．３％，均有统计学显著性意义（Ｐ＜０．００１）。因此，每天两次使用三氯羟苯醚－共聚体牙膏能显著减少牙菌斑的形成，降低龈炎指数和改善牙龈健康。本研究未观察到该牙膏的副作用。A total of one hundred fifty three healthy male and female adults were entered into a six month,doubleblind clinical study designed to evaluate the effect of a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.243% sodium fluoride/silica base, relative to a 0.243% sodium fluoride silica base control dentifrice on supragingival plaque accumulation and gingivitis. Plaque and gingivitis were scored after 3 and 6 months' use of the assigned dentifrice. At the end of the study, the dentifrice containing triclosan/copolymer demonstrated an average reduction, relative to the control dentifrice of 16.1% in plaque accumulation and 24.3% in gingivitis. Both were statistically significant(P<0.001). It was concluded that the twicedaily use of the triclosan/copolymer containing dentifrice resulted in a significant reduction in plaque formation and a significant improvement in gingival health. No sideeffects were observed.

关 键 词：牙膏 三氯羟苯醚 牙龈炎 牙菌斑 

分 类 号：R781.41[医药卫生—口腔医学] R781.1[医药卫生—临床医学]