C型利钠肽对青霉素及海人酸所致癫痫的作用  

EFFECT OF C-TYPE NATRIURETIC PEPTIDE ON THE SEIZURES INDUCED BY PENICILLIN AND KAINIC ACID

作　　者：陈明辉[1] 黄显奋[1] 

机构地区：[1]上海医科大学医学神经生物学国家重点实验室,200032

出　　处：《上海医科大学学报》1997年第6期459-460,共2页Journal of Fudan University(Medical Science)

摘　　要：研究C型利钠肽（C－typenatriureticpeptide，CNP）对青霉素及海人酸（kalnicacid，KA）所致癫痫的作用。以脑电总功率及病性行为分级评分作为癫病发作的指标。结果：CNP（icv，0．16nmol/2μl）本身对脑电图无明显影响，但可明显增加海马注射青霉素（2O0μ/μl，intrahippocampus，ihc）致病后大鼠的脑电总功率，减少腹腔注射KA（iP，8mg/g）后大鼠病性行为的分级评分值。结论：CNP可加强青霉素所致癫痫，抑制KA所致癫痫。PURPOSE The effect of c - type natriuretic peptide (CNP) on the seizure induced by penicillin and kainic acid (KA) was studied.METHODS Electroencephalogram (EEG ) spectrum power and the score of epileptoid behavioral response were used to describe seizure.RESULTS CNP (icv, 0. 16 nmol/2μl) itself did not influence EEG, but it enhanced significantly the EEG spectrum power of epileptic rat induced by penicillin (200 u/μl, intrahippocampus, ihc), while it decreased the score of epileptoid behavioral response of rat treated with KA (ip, 8 mg/kg).CONCLUSIONS CNP can enhance the seizure induced by penicillin and inhibit the seizure induced by KA.

关 键 词：C型利钠肽 青霉素 海人酸 癫痫 

分 类 号：R742.101[医药卫生—神经病学与精神病学]