香菇多糖对小鼠脾T/B淋巴细胞TLR4、TLR9表达的影响  

Influence of lentinan on expression of TLR4,TLR9 of mouse splenic T/B cells

作　　者：彭煦[1] 范晓静[1] 石贤爱[1] 陈剑锋[1] 郭养浩[1] 孟春[1] 

机构地区：[1]福州大学生物科学与工程学院生物工程系,福州350002

出　　处：《中国临床药理学杂志》2008年第3期234-236,共3页The Chinese Journal of Clinical Pharmacology

基　　金：福州大学校科技发展基金资助项目(2005-XQ-10)

摘　　要：目的研究香菇多糖(肿瘤化疗辅助药)产生抗肿瘤作用的分子机制。方法用香菇多糖对体外小鼠脾淋巴细胞的进行刺激,研究香菇多糖对TLR4、TLR9表达的影响。结果香菇多糖在初期可激活TLR4、TLR9的表达;进一步可激活肿瘤坏死因子α的表达。结论香菇多糖通过激活机体的免疫系统具有抑制肿瘤生长的活性。Objective To study the molecular mechanism of entinan on anticancer activity. Methods The effect of addition of lentinan on toll like receptor TLR 4 and TLR 9 expression of splenic T/B lymphatic cells in vitro was examined. Results The lentinan could induce expression of TLR4 and TLR9 initially, and then expression of tumor necrosis factorα. Conclusion The lentinan had anticancer activity through stimulating body＇s immune system.

关 键 词：香菇多糖 肿瘤坏死因子Α 

分 类 号：R962[医药卫生—药理学] R979.19[医药卫生—药学]