血纤溶活性变化对颈动脉粥样硬化和急性脑梗死患者的影响和分析  

The Lever of Plasma Fibrinogen in Carotid Atherosclerosis and Acute Cerebral Infarction

作　　者：汪效松[1] 雷惠新[1] 张旭[1] 程琼[1] 周秀珍[1] 

机构地区：[1]福建省立医院神经内科,350001

出　　处：《中国临床神经科学》2008年第3期242-245,共4页Chinese Journal of Clinical Neurosciences

基　　金：福建省科技基金项目号(No.2001Z158)

摘　　要：目的:研究血纤溶活性变化对颈动脉粥样硬化患者和急性脑梗死患者的影响。方法:67例急性脑梗死患者(ACI组)和62名健康体检老年人(对照组),均行彩色多普勒超声诊断仪超声观察颈动脉有无斑块;同时测定血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物-1(PAI-1)的活性。结果:对照组中有颈动脉斑块者与无颈动脉斑块者相比,血浆t-PA降低,PAI-1升高,P/t值升高(P<0.05);观察组颈动脉斑块发生率明显高于对照组(P<0.05);观察组患者急性期血浆t-PA、PAI-1升高,P/t值减少(P<0.05)。结论:颈动脉硬化时,机体纤溶活性处于减低状态;急性脑梗死发生时,纤溶活性处于相对亢进状态。Aim. To study the plasma fibrinogen level in the patients with carotid atherosclerosis（AS） and acute cerebral infarction（ACI）. Methods： Blood samples were collected from 67 patients with ACI and 62 controls. The level of tissue-type plasminogen activator（t-PA） and plasminogen activator inhibitor-1 （PAI-1） were tested with ELISA. The carotid was observed by B-mode ultrasound. Results： The plasma t-PA was lower and the PAI-1 was higher in carotid atherosclerosis （P〈0.05） .The concentrations of plasma t-PA and PAI-1 were higher in ACI group （P〈0.05）. Conclusion： The relative decrease of fibrinolytic activity was the feature of the patients with carotid atherosclerosis, and relative increase of fibrinolytic activity with ACI.

关 键 词：动脉粥样硬化 脑梗死 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 血浆 

分 类 号：R743[医药卫生—神经病学与精神病学]