甲钴胺对挤压伤大鼠坐骨神经的修复作用  

Recovery Action of Methycobal to Sciatic Nerve Crush Lesion in Rats

作　　者：苏建华[1] 章莉萍[1] 陈玉芳[2] 唐金荣[3] 肖杭[4] 包德诚[1] 

机构地区：[1]金坛市人民医院神经内科,213200 [2]常州市第四人民医院病理科,213001 [3]南京医科大学第一附属医院神经内科,210029 [4]南京医科大学应用神经毒理研究所,210029

出　　处：《中国临床神经科学》2008年第3期266-269,共4页Chinese Journal of Clinical Neurosciences

基　　金：江苏省常州市卫生局资助项目(编号:2004182)

摘　　要：目的:观察甲钴胺对周围神经损害后恢复的影响。方法:以SD大鼠坐骨神经建立周围神经损害动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察甲钴胺对周围神经损害后恢复的影响。结果:甲钴胺组给药4周后能显著改善大鼠坐骨神经损害。结论:甲钴胺对周围神经损害有确切的修复作用。Aim： To study the recovery action of methycobal to peripheral nerve crush lesion in rats. Methods： Sciatic nerve crush lesion model was established in rats.The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron microscope. Results： At the end of 4 weeks, methycobal can obviously recover the sciatic crush lesion in rats. Conclusion： Methycobal shows recovery effect on the peripheral crush lesion.

关 键 词：甲钴胺 周围神经损害 修复作用 大鼠 

分 类 号：R741[医药卫生—神经病学与精神病学]