番茄红素油树脂混合环糊精包合研究  

Study on the Inclusion of Lycopene Oil Resin/Mixed-cyclodextrin

作　　者：孙海松[1] 韩彬彬[1] 任勇[1] 高剑锋[1] 董祥玉 

机构地区：[1]南京师范大学新药研究中心,江苏南京210046 [2]南京巨环医药科技开发有限公司,江苏南京210097

出　　处：《安徽农业科学》2008年第12期4815-4816,4834,共3页Journal of Anhui Agricultural Sciences

基　　金：南京师范大学新药研究中心和南京巨环医药科技有限公司资助项目

摘　　要：[目的]研究混合环糊精（β-环糊精、羟丙基-β-环糊精）对番茄红素油树脂的包合性能并验证其实用性。[方法]紫外法测定番茄红素与β-环糊精、羟丙基-β-环糊精、混合环糊精的包合常数;采用研磨法制备包合物并测定溶解度,考察其稳定性。[结果]番茄红素油树脂与混合环糊精包合常数为758-1 247 L/mol,大于与β-环糊精的416-608 L/mol;高性价比混合环糊精的包合物,其溶解度提高近70倍且稳定性提高。[结论]番茄红素油树脂/混合环糊精包合物实用性大大增强。[Objective] The purpose of the experiment was to study the inclusion performance of mixed-cyclodextrin（β-cyclodextrin,hydroxypropyl-β-cyclodextrin） lycopene oil resin inclusion performance and to certificate its practicality.[Methods] With UV spectrophotometry the inclusion constants of β-cyclodextrin,hydroxypropyl-β-cyclodextrin and mixed-cyclodextrin to Lycopene were detected,respectively.The complexes were prepared by grinding.Their solubility was detected and also their stability was studied.[Results] The inclusion constants of mixed-cyclodextrin to Lycopene oil resin was 758～1 247 L/mol,which was larger than that of β-cyclodextrin,which was 416～608 L/mol.The inclusion compounds of high cost performance mixed-cyclodextrin＇s solubility increased almost 70 times and the stability was improved.[Conclusion] The practicality of Lycopene oil resin/mixed-cyclodextrin was improved significantly.

关 键 词：番茄红素 混合环糊精 包合物 稳定性 

分 类 号：Q946.86[生物学—植物学]