c-met蛋白在高细胞变异型甲状腺乳头状癌中的表达  

c-met Expression in Tall Cell Variant Papillary Carcinoma of The Thyroid

作　　者：张春旭[1] 王强[2] 李延甫[1] 

机构地区：[1]解放军第153中心医院东区普通外科,郑州450007 [2]第二军医大学附属长征医院普通外科,上海200003

出　　处：《中国普外基础与临床杂志》2008年第5期318-322,326,共6页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的比较c-met蛋白在高细胞变异型甲状腺乳头状癌和其他类型甲状腺癌及良性甲状腺组织中表达的差异。方法采用免疫组化SP法分析60例甲状腺组织标本中c-met蛋白的表达。结果高细胞变异型甲状腺乳头状癌中c-met蛋白表达明显高于其他类型乳头状癌和良性甲状腺组织(P=0.0001)。另外,所有甲状腺乳头状癌中有囊外扩散和肌肉侵犯者的c-met蛋白明显高表达(P=0.0100,P=0.0200)。结论c-met蛋白高表达是高细胞变异型甲状腺乳头状癌及其侵袭行为的明显标志,在高细胞变异型甲状腺乳头状癌的早期诊断中有一定作用。Objective To investigate the expression of c-met in tall cell variant of papillary thyroid carcinoma,and to compare it with other types of thyroid carcinoma and benign thyroid tissue. Methods The expressions of c- met in 60 cases of thyroid specimens were tested by immunohistochemical staining. Results The levels of expressed c-met in tall cell variant specimens were significantly higher than those in other types of papillary thyroid carcinoma and benign thyroid tissue, c-met expressions were significantly different in the following pairs of types： tall cell variant vs common papillary carcinoma of thyroid （P= 0. 000 1）, tall cell variant vs follicular variant papillary thyroid carcinoma （P=0. 000 1）, and tall cell variant vs benign thyroid tissue （P=0. 000 1）. In addition, for all types of papillary carcinomas evaluated, c-met expression was significantly higher in specimens with extracapsular spread （P=0. 010 0） and skeletal muscle invasion （P=0. 020 0）. Conclusion The high expression of c-met is a significant marker for tall cell variant papillary carcinoma of thyroid and its invasive behavior. This finding may explain the unusually aggressive behavior of this tumor and suggest a role for c-met in the early identification of patients with tall cell variant thyroid carcinoma.

关 键 词：C-MET蛋白 甲状腺乳头状癌 高细胞变异 侵袭 

分 类 号：R736.1[医药卫生—肿瘤]