机构地区:[1]中国医学科学院北京协和医院眼科,100730
出 处:《中华眼底病杂志》2008年第3期206-209,共4页Chinese Journal of Ocular Fundus Diseases
摘 要:目的观察黄斑前膜手术治疗后的长期效果,评价视力预后与黄斑水肿的关系。方法回顾分析22例经玻璃体切割手术剥离黄斑前膜手术治疗并随诊1年以上的黄斑前膜患者22只眼的临床资料。其中,特发性黄斑前膜17只眼,占77%;继发性黄斑前膜5只眼,占23%。所有患眼治疗前后均进行视力、眼底彩色照相、荧光素眼底血管造影(FFA)以及光相干断层扫描(OCT)检查。视力采用5分记录,FFA、OCT检查按常规方法进行。治疗前手术眼平均视力为(4.25±0.36),黄斑平均厚度为(499±114)μm;对侧眼视力正常,黄斑平均厚度(184±37)μm。黄斑前膜均经手术成功剥除,手术后随访12~40个月,平均随访时间(23±8)个月。回顾分析时,采用线性回归分析的方法,着重对比分析手术前后视力、眼底彩色照相、FFA以及OCT检查结果的相关关系以及手术并发症的发生情况。结果13只眼视力提高,占59%;6只眼视力不变,占27%;3只眼视力减退,占14%。平均视力提高到(4.57±0.31),与治疗前视力比较,差异有统计学意义(t=3.40,P〈0.05)。末次随访视力≥4.5者15只眼,占66%。黄斑平均厚度降低到(286±104)μm,与治疗前黄斑平均厚度比较,差异有统计学意义(t=8.33,P〈0.05)。但仍未恢复到对侧眼水平(t=4.68,P〈0.05)。排除手术后白内障加重未行手术治疗的患眼,手术前后视力与黄斑水肿程度呈线性相关(r=-0.64,P=0.001;r=-0.58,P=0.01)。6只眼手术中剥膜后黄斑区少量点状出血,占27%;2只眼手术中视网膜周边发生裂孔,占9%。5只眼手术后继发高眼压,占23%;1只眼出现黄斑裂孔,占5%;8只眼白内障加重,占36%。结论经玻璃体切割手术剥离黄斑前膜可以减轻黄斑水肿,提高视力,是治疗黄斑前膜的有效方法。Objective To evaluate the long-term result of vitrectomy for macular epiretinal membranes(ERM) and the relationship between best-corrected visual acuity(VA) and macular thickness. Methods In a retrospective consecutive series, twenty-two eyes (17eyes of idiopathic (77%) and 5 of secondary ERM (23%)) of 22 patients with macular ERM who underwent pars plana vitrectomy and membrane peeling which had more than 1 year's (12-40 months, mean (23±8) months)follow up were included. All the patients were examined by VA, fundus color photography, fluorescein fundus angiography (FFA) optical coherence tomography (OCT) before and after treatment. VA was adopted 5 points record; FFA and OCT were underway as common way. The mean of VA was (4.25±0.36), the mean of macular thickness was (499±114) μm. Compared the VA, appearance of fundus photography, fluorescein angiography and optical coherence tomography (OCT) before and after surgery. Results Visual improvement was achieved in 13 eyes (59%), meanwhile, 6 eyes (27%) were stable and 3 eyes (14%) were worse; VA of 15 eyes (66%) was more than 4.5 at last follow-up. The mean VA increased from (4.25±0.36) to (4.57±0.31) postoperatively, the difference was statistically significant (P〈0. 05). Mean macular thickness decreased from (499±114) μm (317-774 μm) to (286±104) μm (150-597 μm) (P〈0.05) postoperatively, the difference was statistically significant (P〈0.05), but still different to the opposite eyes'((184±37) μm)(P〈 0.05 ). VA correlated with macular thickness preoperatively (r=-0.64, P = 0. 001)and postoperatively (r = - 0. 58, P = 0.01) except the patients with cataract improvement without therapy. 6 eyes (27 % ) had retinal hemorrhage and 2 eyes (9 % ) had peripheral retinal breaks intraoperatively; 5 eyes(23%) had secondary higher intraocular pressure, 1 eye (5 %) had macula hole and 8 eyes(36%) had cataract impr
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