Implanting hydroxyapatite-coated porous titanium with bone morphogenetic protein-2 and hyaluronic acid into distal femoral metaphysis of rabbits  

作　　者：彭磊 边卫国 梁芳慧 徐华梓 

机构地区：[1]Department of Orthopedic Surgery, Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical College, Wenzhou 325000, China [2]Northwest Institute for Non-ferrous Metal Research, Xi'an 710016, China

出　　处：《Chinese Journal of Traumatology》2008年第3期179-185,共7页中华创伤杂志（英文版）

摘　　要：Objective： To assess the osseointegration capability of hydroxyapatite-coated porous titanium with bone morphogenetic protein-2 （BMP-2） and hyaluronic acid to repair defects in the distal femur metaphysis in rabbits. Methods： Porous titanium implants were made by sintering titanium powder at high temperature, which were coated with hydroxyapatite by alkali and heat treatment and with BMP-2 combined with bone regeneration materials. And hyaluronic acid was further used as delivery system to prolong the effect of BMP-2. The implants were inserted into the metaphysis of the distal femur of rabbits. The animals were killed at 6, 12 and 24 weeks to accomplish histological and biomechanical analyses. Results： According to the result of histological analysis, the osseointegration in BMP-2 group was better than that of the HA-coated porous titanium group. In push-out test, all the samples had bigger shear stress as time passed by. There was statistical difference between the two groups in 6 and 12 weeks but not in 24 weeks. Conclusion： Hydroxyapatite-coated porous titanium with BMP-2 and hyaluronic acid has a good effect in repairing defects of distal fumur in rabbits, which is a fine biotechnology for future clinical application.

关 键 词：Porous titanium Bone morphogenetic protein-2 HYDROXYAPATITE OSTEOINTEGRATION Hyaluronic acid 

分 类 号：R68[医药卫生—骨科学]