相关期刊:《Journal of Wuhan University of Technology(Materials Science)》《Chinese Journal of Traumatology》《Regenerative Biomaterials》《Science China Materials》更多>>
supported by the National Key R&D Program of China(No.2023YFB4603500);the Program for Innovation Team of Shaanxi Province(No.2023-CX-TD-17);the Fundamental Research Funds for the Central Universities;the Shaanxi Province Qinchuangyuan“Scientist+Engineer”Team Construction Project(No.2022KXJ-106).
The bioinert nature of polyether ether ketone(PEEK)material limits the widespread clinical application of PEEK implants.Although the porous structure is considered to improve osseointegration of PEEK implants,it is ha...
supported by the Key research and development program of Hunan Province(Grant No.2020SK2008 and 2021GK2012);the Major science and technology projects of Changsha City(Grant No.kh2003016);Clinical research fund of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2020LNJJ15);The Natural Science Foundation Exploration Project of Zhejiang Province,China(Grant No.Y23H060040);the Natural Science Foundation of Hunan Province,China(Grant No.2022JJ30934).
Infected bone defects(IBDs)remains a challenging problem for orthopedists.Clinically,routine management for IBDs has two stages:debridement and systematic antibiotics administration to control infection,and secondary ...
supported by the National Natural Science Foundation of China(Grant numbers 32071327,32101087);Shaanxi Science and Technology Association(2022JQ-312).
Endowing implant surfaces with combined antibacterial and osteogenic properties by drug-loaded coatings has made great strides,but how to achieve the combined excellence of infection-triggered bactericidal and in vivo...
supported by the National Natural Science Foundation of China(Nos.51771142 and 51971171);Natural Science Foundation of Shaanxi Province(No.2021JC-07).
Infection is a main cause of implant failure.The microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent osteointegration.Based on the su...
supported by the Science Foundation of Shandong Province of China[Grant No.ZR2021MH026,ZR2022MH075];Medicine and Health Science Technology Development plan of Shandong Province of China[Grant No.202108020440,2020Q127];Liaocheng Key Research and Development Plan of Shandong Province of China[Grant No.2022YDSF16,2022YDSF21];Liaocheng People’s Hospital Youth Fund Project[Grant No.LYQN201914].
Immune response is an important factor in determining the fate of bone replacement materials,in which macrophages play an important role.It is a new idea to design biomaterials with immunomodulatory function to reduce...
supported by the National Natural Science Foundation of China[81972058 and 81902194];the Science and Technology Commission of Shanghai Municipality[22YF1422900 and 21002411200];the Shanghai Municipal Key Clinical Specialty,China[shslczdzk06701];Huangpu District Industrial Support Fund[XK2020009];the National Facility for Translational Medicine(Shanghai),China[TMSZ-2020-207];the Shanghai Engineering Research Center of Orthopedic Innovative Instruments and Personalized Medicine Instruments and Personalized Medicine[19DZ2250200].
Osteoporosis results in decreased bone mass and insufficient osteogenic function.Existing titanium alloy implants have insufficient osteoinductivity and delayed/incomplete fracture union can occur when used to treat o...
the National Natural Science Foundation of China(No.52122102);the Natural Science Foundation of Guangdong(No.2019A1515011755);the Shenzhen Fundamental Research Project(No.JCYJ20190809153205492)。
The biocompatible metallic implants with strong osteointegration often lack the ability of anti-infection.The biocompatible niobium(Nb)containing the antibacterial copper(Cu),the obtained Nb-Cu alloy,could be a potent...
Designing and developing metal implants as permanent hard tissue substitutes to achieve both osteointegration and energy-dissipation has been a long-standing theme of fundamental and clinical research[1].However,these...
This work was supported by the National Natural Science Foundation of China(No.31570989);the Young Talents Project of Zhejiang Provincial Health Department(No.2019RC151);the Zhejiang Provincial Welfare Technology Research Project(No.LGF20H140007),China.
Polyetheretherketone(PEEK)has been widely applied in orthopedics because of its excellent mechanical properties,radiolucency,and biocompatibility.However,the bioinertness and poor osteointegration of PEEK have greatly...
supported by the Key Program for Foreign Cooperation of Chinese Academy of Sciences[grant number 174321KYSB20180006];the National Natural Science Foundation of China[grant number 51631009];the International Cooperation Program of Shenzhen Science and Technology Innovation Commission(grant number GJHZ20190821160803823).
Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture.However,the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing a...