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Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes
《Genes & Diseases》2025年第2期425-437,共13页Pan Li Chao Zheng Jingyan Hu Weiguang Lu Dong Wang Xue Hao Chengxiang Zhao Liu Yang Zhuojing Luo Qiang Jie 
supported by the National Natural Science Foundation of China (No.82272442,82372361);the Key Industrial Chain Program of Shaanxi,China (No.2022ZDLSF02-12).
Although the pathogenesis and mechanism of congenital skeletal dysplasia are bet-ter understood,progress in drug development and intervention research remains limited.Here we report that melatonin treatment elicits a ...
关键词：Ca^(2+)overload CHONDRODYSPLASIA Endoplasmic reticulum stress MELATONIN SLC26A2 
Three-dimensional multi-constraint analytical capture zone against maneuvering targets with velocity advantages
《Chinese Journal of Aeronautics》2025年第2期286-304,共19页Wenxue CHEN Yudong HU Changsheng GAO Ruoming AN 
Concerning the capture problem against arbitrary maneuvering targets,whose overload is high maneuvering but upper bounded and velocity has advantages,this paper elucidates a three-dimensional multi-constraint analytic...
关键词：Analytical capture zone Motion camouflage technique Field of view constraint Overload saturation Missiles 
Three-body cooperative active defense guidance law with overload constraints:A small speed ratio perspective
《Chinese Journal of Aeronautics》2025年第2期226-243,共18页Shuangxi LIU Zehuai LIN Yichong WANG Wei HUANG Binbin YAN Yong LI 
support provided by the National Natural Science Foundation of China(No.62173274);the National Key R&D Program of China(No.2019YFA0405300);the Natural Science Foundation of Hunan Province of China(No.2021JJ10045);Shanghai Aerospace Science and Technology Innovation Fund,China(No.SAST2020-004);Postdoctoral Fellowship Program of CPSF(No.GZB20240989);the Open Research Subject of State Key Laboratory of Intelligent Game,China(No.ZBKF-24-01).
In air combat,one effective way to counter an incoming missile attacking an aircraft is to launch a defense missile compared with traditional passive defense strategies such as decoy and electronic countermeasures.To ...
关键词：Three-body active defense Cooperative guidance Guidance law Overload constraint Small speed ratio Sliding mode control 
Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+overload
《Science China(Life Sciences)》2025年第2期484-501,共18页Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shu-Zhen Huang Richard H.Finnell Fanyi Zeng 
supported by the National Key Research and Development Program of China(2019YFA0801402);the National Natural Science Foundation of China(82271890);the Shanghai Key Clinical Specialty Project(shslczdzk05705);the Shanghai Top Priority Key Discipline Project(2017ZZ02019);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);the Macao Science and Technology Development Fund(FDCT)(0092/2022/A2,003/2022/ALC)。
Autosomal recessive spinocerebellar ataxias(SCARs)are one of the most common neurodegenerative diseases characterized by progressive ataxia.Although SCARs are known to be caused by mutations in multiple genes,there ar...
关键词：AFG3L2 gene autosomal recessive spinocerebellar ataxia mitochondrial impairment Ca2+overload 
Luring cooperative capture guidance strategy for the pursuit—evasion game under incomplete target information
《Astrodynamics》2024年第4期675-688,共14页Wenxue Chen Yudong Hu Changsheng Gao Wuxing Jing 
cosupported by the National Natural Science Foundation of China(Nos.12072090 and 12302056);the Postdoctoral Fellowship Program of CPSF(No.GZC20233445);the Heilongjiang Postdoctoral Financial Assistance(No.LBH-Z23147).
In this work,we attempt to investigate a luring cooperative guidance strategy for three-player inducer–defender–attacker engagement with field-of-view(FOV)and overload constraints against an attacker with speed adva...
关键词：adaptive backstepping luring defense technology overload constraint field-of-view(FOV)constraint missile guidance distributed cooperative 
Recurrent spinal subdural hematoma following percutaneous kyphoplasty:A unique case report
《Chinese Journal of Traumatology》2024年第6期354-358,共5页Wen-Hui Liu Xin-Min Lin Xin-Yu Lu Hai Han Liang-Zhi Zhang Hai-Xian Lin Zi-Wen Liu 
Spinal intradural(subdural and subarachnoid)hematoma following percutaneous kyphoplasty is an extremely rare complication.In this report,we described a case of 2 episodes of subarachnoid hemorrhage with delayed paraly...
关键词：Spinal subarachnoid hemorrhage Rare complication Osteoporotic vertebral fracture(OVF) Venous overload Percutaneous kyphoplasty Case report 
Daytime Heat Stress, Thermal Pattern, Hyperthermia and Body Caloric Overload in Tropical Acclimatized Holstein and Jersey Heifers
《Open Journal of Animal Sciences》2024年第4期260-287,共28页Edil E. Araúz-Santamaría Bryan G. Mendieta-Araica Roderick A. González-Murray Gustavo A. Crudeli David Berroa-Pinzón Ernesto R. Varillas-Esquivel 
The influence of daytime tropical heat stress in the summer was studied in Holstein and Jersey heifers already acclimatized to tropical environments to determine their physiological response based on body thermal patt...
关键词：ACCLIMATIZATION Dairy Cattle Heat Stress Index Rectal Temperature Summer Temperature Humidity Index 
Senior Phones,Young Users Dialing back the clock to fight digital overload
《Beijing Review》2024年第46期38-39,共2页Yuan Yuan 
Locking her smartphone in a desk drawer and taking out a feature phone before leaving the office every day is the strategy that Liu Xinran,a 26-year-old client manager at a trading company in Chongqing Municipality,so...
关键词：CLIENT CHONGQING TRADING 
Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients
《World Journal of Diabetes》2024年第10期2123-2134,共12页Xi-Jin Deng Yi-Nan Wang Chuan-Bao Lv Zhong-Zhi Qiu Ling-Xin Zhu Jing-Hui Shi Si-Ri-Gu-Leng Sana 
Supported by the Natural Science Foundation of Heilongjiang Province,No.LH2022H035;the First Affiliated Hospital of Harbin Medical University Foundation,No.2024JQ14.
BACKGROUND Cardiopulmonary bypass(CPB)is a common procedure in cardiac surgery.CPB is a high-risk factor for acute kidney injury(AKI),and diabetes is also such a factor.Diabetes can lead to copper overload.It is curre...
关键词：Cardiopulmonary bypass Acute kidney injury Cuproptosis DIABETES Copper overload Iron-sulfur cluster proteins 
PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function
《Bone Research》2024年第3期621-633,共13页Yan Shao Hongbo Zhang Hong Guan Chunyu Wu Weizhong Qi Lingfeng Yang Jianbin Yin Haiyan Zhang Liangliang Liu Yuheng Lu Yitao Zhao Sheng Zhang Chun Zeng Guiqing Wang Xiaochun Bai Daozhang Cai 
supported by grants from Natural Science Foundation of China grant No 82172491 (CN);National Natural Science Funds for Excellent Young Scholar No 82322044 (CN);National Key Research and Development Program of China (2022YFC3601902);Youth Talent Support Programme of Guangdong Provincial Association for Science and Technology (SKXRC202308);State-funded postdoctoral researcher program No GZC20231062 (CN)。
Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte ...
关键词：OVERLOAD aging stress 
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