Immunomodulation and osteointegration of infected implants by ion-riched and hierarchical porous TiO_(2)matrix  

作　　者：Yang Xue Lan Zhang Fuwei Liu Liang Kong Yong Han 

机构地区：[1]State-key Laboratory for Mechanical Behavior of Materials,Xi’an Jiaotong University,Xi’an 710049,China [2]State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases,Department of Oral and Maxillofacial Surgery,School of Stomatology,The Fourth Military Medical University,Xi’an 710032,China

出　　处：《Nano Research》2023年第2期2905-2914,共10页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51771142 and 51971171);Natural Science Foundation of Shaanxi Province(No.2021JC-07).

摘　　要：Infection is a main cause of implant failure.The microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent osteointegration.Based on the superiority of photothermal therapy in anti-infection,a matrix of nanograined TiO_(2)with(Si/P)-dual ions and hierarchical nano/microporous topography is developed on Ti implant by micro-arc oxidation.It shows good photothermal properties due to the lattice distortion induced by ion doping and can kill bacteria with near-infrared(NIR)light irradiation efficiently.Due to the combined action of porous topography and release of Si/P ions,the TiO_(2)matrix achieves M1-to-M_(2)phenotype switch of macrophages timely at different simulating infection stage and accelerates recruitment,proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.In vivo,the TiO_(2)matrix also shows desired antibacterial performance after photothermal therapy and exhibits outstanding immunomodulatory ability and new bone formation efficiency.This study provides a promising TiO_(2)matrix applied in clinic for settling implant infection by NIR light irradiation and promoting bone regeneration through osteoimmunomodulation.

关 键 词：PHOTOTHERMAL ANTIBACTERIAL IMMUNOMODULATION OSTEOINTEGRATION 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]